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EC Number	Localization	Commentary	GeneOntology No.	Reference
2.5.1.6	nucleus	isoform MAT I, in extrahepatic tissues, the protein colocalizes with nuclear matrix markers. Presence of two partially overlapping areas at the C-terminal end of the protein involved both in cytoplasmic retention and nuclear localization. Neither nuclear localization nor matrix binding requires activity. Nuclear accumulation of the active enzyme only correlates with histone H3K27 trimethylation among the epigenetic modifications evaluated	GO:0005634 AmiGO QuickGO	703614
2.5.1.6	cytoplasm	isoform MAT I, presence of two partially overlapping areas at the C-terminal end of the protein involved both in cytoplasmic retention and nuclear localization	GO:0005737 AmiGO QuickGO	703614
2.5.1.6	cytosol	-	GO:0005829 AmiGO QuickGO	639048, 639053, 639054, 686024, 738224
2.5.1.6	cytosol	S-adenosylmethionine synthetase A	GO:0005829 AmiGO QuickGO	639048
2.5.1.6	cytosol	S-adenosylmethionine synthetase B	GO:0005829 AmiGO QuickGO	639048

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Release 2023.1 (January 2023)