EC Number |
Localization |
GeneOntology No. |
Reference |
---|
2.3.1.B41 | cytoplasmic stress granule |
SIRT6 translocates into the cytoplasm under stress and regulates formation as well as disassembly of stress granules |
GO:0010494 AmiGO QuickGO |
730101 |
2.3.1.B41 | nucleosome |
SIRT6 activity is nucleosome dependent, and suggest that its binding to the nucleosome might convert it into an active structure |
GO:0000786 AmiGO QuickGO |
730498 |
2.3.1.B41 | mitotic spindle |
Sirt6 partially colocalizes with mitotic spindles |
GO:0072686 AmiGO QuickGO |
730527 |
2.3.1.B41 | nucleolus |
Sirt6 is enriched in the nucleolus in the G1 phase of the cell cycle, while S phase nucleoli are almost entirely free of Sirt6 |
GO:0005730 AmiGO QuickGO |
730527 |
2.3.1.B41 | nucleus |
during interphase, Sirt6 is mostly localized to the nucleus |
GO:0005634 AmiGO QuickGO |
730527 |
2.3.1.B41 | nucleosome |
- |
GO:0000786 AmiGO QuickGO |
755787 |
2.3.1.B41 | nucleus |
- |
GO:0005634 AmiGO QuickGO |
755787, 756392, 756407, 756672, 756689, 757236, 757931, 758437 |
2.3.1.B41 | nucleus |
the C-terminus of SIRT6 is required for nuclear localization of the enzyme |
GO:0005634 AmiGO QuickGO |
755918 |
2.3.1.B41 | nucleus |
SIRT6 and Per2 co-localize in the nucleus |
GO:0005634 AmiGO QuickGO |
755978 |
2.3.1.B41 | intracellular |
- |
GO:0005622 AmiGO QuickGO |
756689 |