EC Number   |
Inhibitors |
Structure  |
|---|
   7.2.1.1 | more |
not inhibited by 0.04 mM Ag+ |
 |
| 7.2.1.1 | more |
the enzyme is fully resistant to either Ag+ or N-ethylmaleimide |
|
| 7.2.1.1 | more |
Na+-NQR from Azotobacter vinelandii is not sensitive to low 2-n-heptyl-4-hydroxyquinoline-N-oxide concentrations |
|
| 7.2.1.1 | more |
korormicin has no effect on the enzyme from Haemophilus influenza |
|
| 7.2.1.1 | more |
Na+-NQR from Klebsiella pneumoniae is fully resistant to either Ag+ or N-ethylmaleimide |
|
| 7.2.1.1 | more |
replacement of the conserved Cys377 residue with alanine in the NqrF subunit results in resistance of the enzyme to Ag+ and to other heavy metal ions; the enzyme is sensitive against SH reagents. Modification of Cys383 by heavy metal ions or by SH reagents can prevent hydride ion transport from NADH to FAD and hence interrupt the Na+-NQR activities |
|
| 7.2.1.1 | NAD+ |
competitive inhibitor |
  |
| 7.2.1.1 | NADH |
incubation of the aerobic enzyme with NADH in the absence of an electron acceptor, the enzyme is destroyed with a half-inactivation time of about 2 min |
|
| 7.2.1.1 | Zn2+ |
- |
|
| 7.2.1.1 | Zn2+ |
93% inhibition at 0.1 M, addition of 0.1 mM of Zn2+ to the reaction medium results in almost complete inhibition of dNADH:K3 oxidoreductase activity of membrane vesicles from the wild-type strain |
|
