EC Number   |
Inhibitors |
Structure  |
|---|
    3.5.4.16 | more |
no inhibition by EGTA |
 |
| 3.5.4.16 | more |
synthesis and inhibitory potential of 7-deazaguanine derivatives on GTPCH I, inhibitory mechanism, overview |
|
| 3.5.4.16 | more |
Mn2+ enzyme is not inactivated by exposure to oxygen |
|
| 3.5.4.16 | more |
GTP-CH1 activity can be inhibited by tetrahydrobiopterin through its protein-protein interactions with GTP-CH1 regulatory protein |
|
| 3.5.4.16 | more |
asymmetric dimethylarginine, ADMA, decreases GCH1 protein, but not mRNA concentrations, in pulmonary arterial endothelial cells because of the ubiquitination and proteasome-dependent degradation of GCH1. Overexpression of CHIP potentiates, whereas a CHIP U-box domain mutant attenuates, ADMA-induced GCH1 degradation and reductions in cellular BH4 concentrations. L-Arginine acts antagonistic and restores the activities |
|
| 3.5.4.16 | more |
the N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP. The autoinhibitory peptide provides a molecular mechanism for physiological up-regulation of GTPCH activity |
|
| 3.5.4.16 | ATP |
- |
  |
| 3.5.4.16 | ATP |
competitive inhibitor |
|
| 3.5.4.16 | ATP |
competitive inhibition |
|
| 3.5.4.16 | Mg2+ |
- |
|
