EC Number |
Inhibitors |
Structure |
---|
3.1.3.67 | 4-hydroxynonenal |
- |
|
3.1.3.67 | phosphatidylserine |
0.2 mM, 75% loss of activity |
|
3.1.3.67 | Mg2+ |
divalent cation required, maximal activition at 1 mM, inhibition above 1 mM |
|
3.1.3.67 | H2O2 |
H2O2 reversibly inhibits PTEN activity by covalently linking Cys-71 to Cys-124, inhibition partially reverses by inclusion of 100 mM dithiothreitol to the buffer |
|
3.1.3.67 | Ca2+ |
in presence of 1 mM Mg2+, slight activation up to 0.01 mM, significant inhibition above 0.1 mM |
|
3.1.3.67 | Laminin |
laminin medium induces PTEN upregulation decreases transcription factor Sp1-binding activity |
|
3.1.3.67 | reactive oxygen species |
oxidation of the active site cysteine by reactive oxygen species inhibits PTEN |
|
3.1.3.67 | more |
PTEN function is very frequently lost during the development of epithelial-derived tumors, and many such tumors are believed to undergo a form of epithelial to mesenchymal transition before these metastasize |
|
3.1.3.67 | more |
PTEN is inhibited by cyclic strain: cyclic strain increases phosphatidylinositol 3,4,5-trisphosphate immunofluorescence and peaks at 60 min after cyclic strain stimulation by 1.93fold in endothelial cells |
|