EC Number   |
Inhibitors |
Structure |
|---|
   3.1.1.81 | 2-hydroxyquinoline |
a specific reversible competitive inhibitor of h-PON1 that is known to bind in the active site of the enzyme and inhibit the hydrolytic activities of the enzyme |
   |
| 3.1.1.81 | Ag+ |
complete inhibition at 0.2 mM |
|
| 3.1.1.81 | Ag+ |
complete inhibition at 1 mM |
|
| 3.1.1.81 | Ag+ |
1 mM, 79% inhibition. 10 mM, 80% inhibition |
|
| 3.1.1.81 | alpha-chymotrypsin |
the enzyme maintains 87% and 101% activity after preincubations with alpha-chymotrypsin at 37°C for 30 min and 60 min |
|
| 3.1.1.81 | amoxicillin |
- |
|
| 3.1.1.81 | Ca2+ |
absolutely required for activity, but inhibitory at higher concentrations, e.g. at 2 mM |
|
| 3.1.1.81 | Ca2+ |
1 mM, about 30% inhibition, in vivo and in vitro assay |
|
| 3.1.1.81 | Ca2+ |
1 mM, complete inhibition |
|
| 3.1.1.81 | Ca2+ |
1 mM, 30% inhibition. 5 mM, 45% inhibition |
|
