EC Number |
Inhibitors |
Structure |
---|
2.7.7.35 | more |
no inhibition by CN-, 1,10-phenanthroline, 2,2'-dipyridyl, ribose 1-phosphate, ribose 1,5-diphosphate, glucose 1-phosphate, glucose 6-phosphate; no inhibition by NADP+, EDTA, ribose |
|
2.7.7.35 | more |
no inhibition by adenosine, deoxyadenosine, 3'-AMP, CMP, CDP, UDP, NADH, NAD+, ADPglucose, UDPglucose, IAA, NEM; no inhibition by NADP+, EDTA, ribose |
|
2.7.7.35 | more |
- |
|
2.7.7.35 | more |
identification of inhibitors by large-scale molecular dynamics simulations. Eight compounds show stable binding modes in the simulations, as well as favorable drug properties. The inhibitors show hydrogen bonds to Leu126, Ala154, and Ile23 |
|
2.7.7.35 | ATP |
kinetics |
|
2.7.7.35 | ATP |
- |
|
2.7.7.35 | ADP |
weak, ADP-ribose phosphorolysis |
|
2.7.7.35 | AMP |
kinetics |
|
2.7.7.35 | AMP |
- |
|
2.7.7.35 | PCMB |
ADP/phosphate-exchange, reversible by cysteine |
|