EC Number |
Inhibitors |
Structure |
---|
2.4.1.102 | 12-O-tetradecanoylphorbol-13-acetate |
about 10fold decreased activity, down-regulation of native enzyme in KM3 leukemia cell line, but not of the recombinant enzyme; i.e. TPA |
|
2.4.1.102 | 5,5'-dithiobis-2-nitrobenzoic acid |
inactivation is partially prevented by prior addition of donor or acceptor substrate and by sulfhydryl reducing agents. 1 mM inhibits 94% |
|
2.4.1.102 | beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl |
high concentration |
|
2.4.1.102 | beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl |
and other nitrophenyl-sugar-derivatives; strong inhibition under UV-radiation at 350 nm, specific for substrate binding site, preincubation with beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl partially protects |
|
2.4.1.102 | Ca2+ |
slight inhibition |
|
2.4.1.102 | Cu2+ |
- |
|
2.4.1.102 | diethyldicarbonate |
0.2 mM, 74% inhibition |
|
2.4.1.102 | EDTA |
slight inhibition |
|
2.4.1.102 | Hydroxyphenylglyoxal |
19% inhibition at 0.25 mM, complete inhibition at 5-10 mM |
|
2.4.1.102 | iodoacetate |
0.2 mM inhibits the enzyme 70% |
|