EC Number   |
Inhibitors |
Structure |
|---|
    1.4.3.2 | 1,10-phenanthroline |
complete inhibition of isoform LAAOII and about 30% inhibition of isoform LAAOI at 5 mM |
   |
| 1.4.3.2 | 2-aminobenzoic acid |
three and two binding sites in isoforms L1 and L2, respectively |
|
| 1.4.3.2 | 2-mercaptoethanol |
complete inhibition of isoform LAAOII and about 50% inhibition of isoform LAAOI at 5 mM |
|
| 1.4.3.2 | 2-mercaptoethanol |
- |
|
| 1.4.3.2 | 2-naphthol |
- |
|
| 1.4.3.2 | 6-chloro-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid |
derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines |
|
| 1.4.3.2 | 6-hydroxy-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid |
derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines |
|
| 1.4.3.2 | 8-hydroxyquinoline |
76% residual activity at 1 mM (pH 5.5) |
|
| 1.4.3.2 | 8-hydroxyquinoline |
2% residual activity at 1 mM |
|
| 1.4.3.2 | 8-hydroxyquinoline |
70.07% inhibition at 10 mM |
|
