EC Number   |
Inhibitors |
Structure  |
|---|
   3.4.21.41 | more |
specific c-Jun amino-terminal kinase inhibitor and the MEK-1 inhibitor PD98059 do not regulate C1r mRNA expression, whereas JSH-23, which inhibits nuclear translocation of NF-kappaB decreases C1r expression selectively in MEF-2 cells |
 |
| 3.4.21.41 | more |
above 0.0005 mM C1rbar the enzyme aggregates with loss of activity |
|
| 3.4.21.41 | more |
high ionic strength inhibits |
|
| 3.4.21.41 | Ca2+ |
reaction with C1s |
  |
| 3.4.21.41 | NaCl |
above 200 mM |
|
| 3.4.21.41 | leupeptin |
competitive |
|
| 3.4.21.41 | diisopropyl fluorophosphate |
- |
|
| 3.4.21.41 | phenylmethylsulfonyl fluoride |
- |
|
| 3.4.21.41 | C1-inhibitor |
regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview |
|
| 3.4.21.41 | C1 inhibitor |
during complex formation, C1 inhibitor dissociates C1r and C1s from the activated C1 macromolecule, a process that is determined primarily by the interaction with C1r |
|
