EC Number |
Inhibitors |
Structure |
---|
2.3.1.286 | more |
no inhibition at 0.05 mM: (5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; no inhibition at 0.05 mM: (5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; no inhibition by EX-527, HR 103 or Ro 31-8220; no inhibition by EX-527, HR 103 or Ro 31-8220; no inhibition by EX-527, HR 103 or Ro 31-8220 |
|
2.3.1.286 | more |
not inhibited by benzamide |
|
2.3.1.286 | o-phenanthroline |
- |
|
2.3.1.286 | nicotinamide |
- |
|
2.3.1.286 | nicotinamide |
mixed noncompetitive inhibitor. Inhibition of SIRT3 involves apparent competition between the inhibitor and the enzyme cofactor NAD+; predominantly noncompetitive inhibitor |
|
2.3.1.286 | nicotinamide |
0.5 mM, complete inhibition |
|
2.3.1.286 | nicotinamide |
noncompetitive inhibitor versus NAD+ |
|
2.3.1.286 | nicotinamide |
noncompetitive inhibitor versus NAD+. 95% inhibition at 1.5 mM |
|
2.3.1.286 | nicotinamide |
noncompetitive inhibitor |
|
2.3.1.286 | suramin |
- |
|