EC Number   |
Inhibitors |
Structure |
|---|
   3.2.1.209 | Co2+ |
50% reduction in alpha-mannosidase activity is observed after addition of 3 mM CoCl2 |
   |
| 3.2.1.209 | cycloheximide |
inhibitory effect like kifunensine |
|
| 3.2.1.209 | D-mannonolactam amidrazone |
inhibitor is a mimic of the mannopyranosyl cation and acts as a potent broad spectrum mannosidase inhibitor. It is inactive against processing glucosidases I and II |
|
| 3.2.1.209 | deoxymannojirimycin |
degradation is inhibited by the the mannosidase inhibitor |
|
| 3.2.1.209 | dithiothreitol |
loss of activity with first-order kinetics |
|
| 3.2.1.209 | EDTA |
- |
|
| 3.2.1.209 | EDTA |
addition of Ca2+ reverses inhibitory effect |
|
| 3.2.1.209 | EDTA |
Ca2+ restores |
|
| 3.2.1.209 | EDTA |
complete inactivation at 1.7 mM, Ca2+ restores |
|
| 3.2.1.209 | EGTA |
complete inhibition at 5 mM |
|
