EC Number |
Inhibitors |
Structure |
---|
2.7.2.8 | L-arginine |
feedback inhibition. SYPA5-5 N-acetylglutamate kinase feedback inhibition by L-arginine can be deregulated by introducing point mutations, H268N or R209A |
|
2.7.2.8 | L-arginine |
feedback inhibition, almost complete inhibition at 10 mM |
|
2.7.2.8 | L-arginine |
wild type enzyme activity drastically decreases by addition of 0.2 mM L-Arg, and consequently decreases when L-Arg concentration is increased, indicating that the enzyme activity is subject to feedback inhibition by L-Arg. Enzyme activity is almost lost in the presence of 1.0 mM L-Arg |
|
2.7.2.8 | L-arginine methyl ester |
1 mM, 80% inhibition |
|
2.7.2.8 | L-canavanine |
- |
|
2.7.2.8 | L-citrulline |
- |
|
2.7.2.8 | MgCl2 |
inhibition above 20 mM |
|
2.7.2.8 | MgCl2 |
30 mM, slight inhibition |
|
2.7.2.8 | more |
not inhibitory: D-arginine, agmatine, citrulline, L-canavanine, L-lysine, L-ornithine, guanidinium ions, urea at 1 mM, 37°C |
|
2.7.2.8 | more |
the enzyme is L-arginine-insensitive |
|