Ligand L-citrulline

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Basic Ligand Information

Molecular Structure
Picture of L-citrulline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13N3O3
L-citrulline
RHGKLRLOHDJJDR-BYPYZUCNSA-N
Synonyms:
L-Citrullin, N-carbamoyl-L-ornithine, N5-carbamoyl-L-ornithine

Show all pahtways known for Show all pathways known for L-citrulline

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-citrulline + H2O = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + L-ornithine = phosphate + N-carbamoyl-L-ornithine
show the reaction diagram
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-
N2-acetyl-L-citrulline + H2O = L-citrulline + acetate
show the reaction diagram
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L-arginine + H2O = L-citrulline + NH3
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Substrate in Enzyme-catalyzed Reactions (59 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-Citrulline + pyruvate + NADPH = N2-(D-1-Carboxyethyl)-L-citrulline + NADP+ + H2O
show the reaction diagram
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phenylpyruvate + L-citrulline = phenylalanine + 2-oxo-5-ureido-pentanoate
show the reaction diagram
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L-citrulline + H2O = (2S)-2-amino-5-(carboxyamino)pentanoic acid + NH3
show the reaction diagram
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L-citrulline + H2O = ?
show the reaction diagram
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N-carbamoyl-L-ornithine + H2O = L-ornithine + CO2 + NH3
show the reaction diagram
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2-Oxobutanoate + L-citrulline = ?
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L-Citrulline = D-Citrulline
show the reaction diagram
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L-Citrulline = D-Citrulline
show the reaction diagram
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ATP + L-citrulline + tRNACCCG = AMP + diphosphate + L-citryl-tRNACCCG
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Product in Enzyme-catalyzed Reactions (74 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + L-ornithine = phosphate + N-carbamoyl-L-ornithine
show the reaction diagram
-
-
N2-acetyl-L-citrulline + H2O = L-citrulline + acetate
show the reaction diagram
-
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Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
; pH 7.6, 30°C
-
10 mM, 75% inhibition
-
1% cell growth, 1% viability of cells
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3D Structure of Enzyme-Ligand-Complex (PDB) (21 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.08
-
pH 8.0, 30°C

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
22
-
L-Met, with pyruvate and NADPH as cosubstrate; with pyruvate and NADPH as cosubstrates
17.1
-
-
10.4
-
pH 8.0, 37°C
9.47
-
pH 8.0, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
20.6
-
pH 7.6, 30°C; pH 7.6, 30°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
30
-
pH 7.5, 37°C
3.7
-
pH 7.3, temperature not specified in the publication

References & Links

Links to other databases for L-citrulline

ChEBI
PubChem
ChEBI
PubChem