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Ligand L-citrulline

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

urea cycle

KEGG

Arginine biosynthesis, Biosynthesis of amino acids, Biosynthesis of antibiotics, Biosynthesis of secondary metabolites

MetaCyc

L-arginine biosynthesis I (via L-ornithine), L-arginine biosynthesis II (acetyl cycle), L-arginine biosynthesis III (via N-acetyl-L-citrulline), L-arginine biosynthesis IV (archaebacteria), L-arginine degradation V (arginine deiminase pathway), L-citrulline biosynthesis, L-citrulline degradation, L-proline biosynthesis II (from arginine), nitric oxide biosynthesis I (plants), nitric oxide biosynthesis II (mammals), nitric oxide biosynthesis III (bacteria), urea cycle more

Show all BRENDA pathways known for L-citrulline

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (21 results)

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Show Natural Substrate (21 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.20

L-citrulline + H2O = ?

171972, 171968, 171967, 171969

-

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

662377, 662205, 661285, 662254

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

662377, 662205, 661285, 662254

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

662377, 662205, 661285, 662254

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

662377, 662205, 661285, 662254

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

662377, 662205, 661285, 662254

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

651195, 652231, 652242, 652404, 650761

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

651195, 652231, 652242, 652404, 650761

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

651195, 652231, 652242, 652404, 650761

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

651195, 652231, 652242, 652404, 650761

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

651195, 652231, 652242, 652404, 650761

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692659, 725629, 728544, 690765, 690234, 693030, 692607, 690727, 690768, 749045

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692659, 725629, 728544, 690765, 690234, 693030, 692607, 690727, 690768, 749045

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692659, 725629, 728544, 690765, 690234, 693030, 692607, 690727, 690768, 749045

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692659, 725629, 728544, 690765, 690234, 693030, 692607, 690727, 690768, 749045

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692659, 725629, 728544, 690765, 690234, 693030, 692607, 690727, 690768, 749045

2nz2, 3D-view

6.3.4.5

20 entries

In Vivo Product in Enzyme-catalyzed Reactions (17 results)

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Show Natural Product (17 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.13.39

2 L-arginine + 3 NADPH + 4 O2 + 3 H+ = 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O

440229, 440194

-

1.14.13.39

2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O

-

-

1.14.13.39

L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O

-

-

2.1.3.3

carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

485904, 485901, 485898, 485895, 485922, 485925, 485918

4jqo, 3D-view

2.1.3.3

carbamoyl phosphate + L-ornithine = L-citrulline + phosphate

-

4jqo, 3D-view

1.14.13.39

3 entries

2.1.3.3

2 entries

2.1.3.6

carbamoyl phosphate + L-ornithine = phosphate + N-carbamoyl-L-ornithine

-

-

3.5.1.B4

N2-acetyl-L-citrulline + H2O = L-citrulline + acetate

-

-

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

1h70, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2c6z, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2jai, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

1h70, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2c6z, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2jai, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

1h70, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2c6z, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2jai, 3D-view

3.5.3.18

9 entries

3.5.3.6

L-arginine + H2O = L-citrulline + NH3

-

1lxy, 3D-view

Substrate in Enzyme-catalyzed Reactions (59 results)

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Show Substrate (59 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.2

L-citrulline + H2O + O2 = ? + NH3 + H2O2

651026

-

1.4.3.2

L-citrulline + H2O + O2 = N5-carbamoyl-2-oxopentanoic acid + NH3 + H2O2

651026

-

1.4.3.2

L-citrulline + H2O + O2 = 2-oxo-5-ureidovaleric acid + NH3 + H2O2

711874

-

1.4.3.2

3 entries

1.5.1.11

L-Citrulline + pyruvate + NADPH = N2-(D-1-Carboxyethyl)-L-citrulline + NADP+ + H2O

13323

-

2.1.3.3

arsenate + L-citrulline = carbamoylarsenate + L-ornithine

485938

4jqo, 3D-view

2.1.3.3

phosphate + L-citrulline = carbamoylphosphate + L-ornithine

666005, 664807

4jqo, 3D-view

2.1.3.3

phosphate + L-citrulline = carbamoyl phosphate + L-ornithine

701115

4jqo, 3D-view

2.1.3.3

3 entries

2.6.1.28

phenylpyruvate + L-citrulline = phenylalanine + 2-oxo-5-ureido-pentanoate

639949

-

3.4.11.17

L-citrulline + H2O = (2S)-2-amino-5-(carboxyamino)pentanoic acid + NH3

665098

-

3.5.1.20

L-citrulline + H2O = ?

171972, 171968, 171967, 171969

-

3.5.1.57

L-citrullin + H2O = ?

81203

-

3.5.1.57

L-citrulline + H2O = ?

668755

-

3.5.1.57

2 entries

3.5.1.6

N-carbamoyl-L-ornithine + H2O = L-ornithine + CO2 + NH3

720104

-

4.1.1.64

2-Oxobutanoate + L-citrulline = ?

4748

-

5.1.1.10

L-Citrulline = D-Citrulline

2047, 2045, 2041

-

5.1.1.9

L-Citrulline = D-Citrulline

2166, 2165

-

6.1.1.19

ATP + L-citrulline + tRNACCCG = AMP + diphosphate + L-citryl-tRNACCCG

726863

-

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

1593, 1578, 1581, 1583, 1584, 1586, 1595, 1598, 1575, 1580, 1582, 1591, 1592, 1594, 1597, 1596, 1577, 1585, 1587, 1588, 1589, 1573, 1590, 1576, 1579, 1574, 662377, 662205, 661285, 662254

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

1593, 1578, 1581, 1583, 1584, 1586, 1595, 1598, 1575, 1580, 1582, 1591, 1592, 1594, 1597, 1596, 1577, 1585, 1587, 1588, 1589, 1573, 1590, 1576, 1579, 1574, 662377, 662205, 661285, 662254

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

1593, 1578, 1581, 1583, 1584, 1586, 1595, 1598, 1575, 1580, 1582, 1591, 1592, 1594, 1597, 1596, 1577, 1585, 1587, 1588, 1589, 1573, 1590, 1576, 1579, 1574, 662377, 662205, 661285, 662254

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

1593, 1578, 1581, 1583, 1584, 1586, 1595, 1598, 1575, 1580, 1582, 1591, 1592, 1594, 1597, 1596, 1577, 1585, 1587, 1588, 1589, 1573, 1590, 1576, 1579, 1574, 662377, 662205, 661285, 662254

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = AMP + diphosphate + L-argininosuccinate

1593, 1578, 1581, 1583, 1584, 1586, 1595, 1598, 1575, 1580, 1582, 1591, 1592, 1594, 1597, 1596, 1577, 1585, 1587, 1588, 1589, 1573, 1590, 1576, 1579, 1574, 662377, 662205, 661285, 662254

2nz2, 3D-view

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

1j1z, 3D-view

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

1j21, 3D-view

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

1k97, 3D-view

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

1kp3, 3D-view

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + 3-nitro-2-aminopropanoate = ?

1587

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + 3-nitro-2-aminopropanoate = ?

1587

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + 3-nitro-2-aminopropanoate = ?

1587

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + 3-nitro-2-aminopropanoate = ?

1587

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + 3-nitro-2-aminopropanoate = ?

1587

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-methyl-L-Asp = ?

1574

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-methyl-L-Asp = ?

1574

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-methyl-L-Asp = ?

1574

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-methyl-L-Asp = ?

1574

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-methyl-L-Asp = ?

1574

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-hydroxy-DL-Asp = ?

1574

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-hydroxy-DL-Asp = ?

1574

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-hydroxy-DL-Asp = ?

1574

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-hydroxy-DL-Asp = ?

1574

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + threo-beta-hydroxy-DL-Asp = ?

1574

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

675096, 652976, 651195, 653344, 676636, 652231, 652404, 652242, 649104, 650761

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

675096, 652976, 651195, 653344, 676636, 652231, 652404, 652242, 649104, 650761

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

675096, 652976, 651195, 653344, 676636, 652231, 652404, 652242, 649104, 650761

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

675096, 652976, 651195, 653344, 676636, 652231, 652404, 652242, 649104, 650761

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + L-argininosuccinate

675096, 652976, 651195, 653344, 676636, 652231, 652404, 652242, 649104, 650761

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-Asp = ?

1594, 1591, 1579, 1598

2nz2, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692607, 690768, 692659, 693030, 690727, 690765, 725629, 728544, 749045, 690234

1j1z, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692607, 690768, 692659, 693030, 690727, 690765, 725629, 728544, 749045, 690234

1j21, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692607, 690768, 692659, 693030, 690727, 690765, 725629, 728544, 749045, 690234

1k97, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692607, 690768, 692659, 693030, 690727, 690765, 725629, 728544, 749045, 690234

1kp3, 3D-view

6.3.4.5

ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate

692607, 690768, 692659, 693030, 690727, 690765, 725629, 728544, 749045, 690234

2nz2, 3D-view

7.4.2.1

ATP + H2O + L-citrulline/out = ADP + phosphate + L-citrulline/in

686013

-

7.4.2.1

ATP + H2O + citrulline/out = ADP + phosphate + citrulline/in

700356, 720414

-

6.3.4.5

40 entries

7.4.2.1

2 entries

Product in Enzyme-catalyzed Reactions (74 results)

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Show Product (74 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.13.39

2 L-arginine + 3 NADPH + 4 O2 + 3 H+ = 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O

440193, 440195, 440200, 440201, 440204, 440206, 440209, 440217, 440225, 440226, 440234, 440236, 440238, 440239, 440194, 440205, 440216, 440218, 440219, 440233, 440237, 440190, 440191, 440197, 440202, 440203, 440207, 440213, 440228, 440230, 440232, 440211, 440214, 440227, 440229, 440235, 440240, 440231, 440224, 440215, 440196, 440210, 440199, 440192, 440208, 440221, 440220, 440223, 440222, 440198

-

1.14.13.39

Nomega-hydroxy-L-arginine + NADPH + H+ + O2 = L-citrulline + NADP+ + NO + H2O

-

-

1.14.13.39

2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O

-

-

1.14.13.39

L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O

-

-

1.14.14.47

2 L-arginine + 3 reduced flavodoxin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H2O

-

-

1.14.14.47

2 Nomega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O

-

-

1.14.14.47

2 L-arginine + 3 tetrahydrobiopterin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized tetrahydrobiopterin + 4 H2O

-

-

1.14.14.47

2 L-arginine + 3 tetrahydrofolate + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized tetrahydrofolate + 4 H2O

-

-

1.14.14.47

2 Nomega-hydroxy-L-arginine + tetrahydrobiopterin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized tetrahydrobiopterin + 2 H2O

-

-

1.14.14.47

N-omega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O

-

-

2.1.3.3

carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

485911, 485894, 485919, 485900, 485921, 485935, 485934, 485920, 485898, 485926, 485927, 485933, 485902, 485912, 485914, 485917, 485923, 485928, 485899, 485925, 485890, 485892, 485909, 485924, 485893, 485918, 485946, 485903, 485906, 485910, 485932, 485908, 485915, 485922, 485916, 485907, 485904, 485957, 485901, 485905, 485897, 485896, 485945, 485895, 485913, 485891, 209399, 485929, 485930, 485889

4jqo, 3D-view

2.1.3.3

carbamoyl phosphate + L-ornithine = L-citrulline + phosphate

-

4jqo, 3D-view

1.14.13.39

4 entries

1.14.14.47

6 entries

2.1.3.3

2 entries

2.1.3.6

carbamoyl phosphate + L-ornithine = phosphate + N-carbamoyl-L-ornithine

-

-

3.5.1.B4

N2-acetyl-L-citrulline + H2O = L-citrulline + acetate

-

-

3.5.3.15

L-Arg + H2O = L-citrulline + NH3

-

-

3.5.3.15

L-arginine + H2O = L-citrulline + NH3

-

-

3.5.3.15

L-arginine-methyl ester + H2O = L-citrulline + NH3

-

-

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

288971

1h70, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

288971

2c6z, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

288971

2jai, 3D-view

3.5.3.18

N,N-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

652188

1h70, 3D-view

3.5.3.18

N,N-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

652188

2c6z, 3D-view

3.5.3.18

N,N-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

652188

2jai, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

1h70, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2c6z, 3D-view

3.5.3.18

NG,NG-dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2jai, 3D-view

3.5.3.18

Nomega-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

1h70, 3D-view

3.5.3.18

Nomega-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2c6z, 3D-view

3.5.3.18

Nomega-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2jai, 3D-view

3.5.3.18

NG-methyl-L-arginine + H2O = L-citrulline + methylamine

-

1h70, 3D-view

3.5.3.18

NG-methyl-L-arginine + H2O = L-citrulline + methylamine

-

2c6z, 3D-view

3.5.3.18

NG-methyl-L-arginine + H2O = L-citrulline + methylamine

-

2jai, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = methanethiol + L-citrulline

-

1h70, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = methanethiol + L-citrulline

-

2c6z, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = methanethiol + L-citrulline

-

2jai, 3D-view

3.5.3.18

NG-methyl arginine + H2O = L-citrulline + methylamine

-

1h70, 3D-view

3.5.3.18

NG-methyl arginine + H2O = L-citrulline + methylamine

-

2c6z, 3D-view

3.5.3.18

NG-methyl arginine + H2O = L-citrulline + methylamine

-

2jai, 3D-view

3.5.3.18

dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

1h70, 3D-view

3.5.3.18

dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2c6z, 3D-view

3.5.3.18

dimethyl-L-arginine + H2O = L-citrulline + dimethylamine

-

2jai, 3D-view

3.5.3.18

N-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

1h70, 3D-view

3.5.3.18

N-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2c6z, 3D-view

3.5.3.18

N-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2jai, 3D-view

3.5.3.18

N5-(methoxycarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

1h70, 3D-view

3.5.3.18

N5-(methoxycarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

2c6z, 3D-view

3.5.3.18

N5-(methoxycarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

2jai, 3D-view

3.5.3.18

N5-(methylcarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

1h70, 3D-view

3.5.3.18

N5-(methylcarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

2c6z, 3D-view

3.5.3.18

N5-(methylcarbamimidoyl)-L-ornithine + H2O = L-citrulline + ?

-

2jai, 3D-view

3.5.3.18

N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine + H2O = L-citrulline + ?

-

1h70, 3D-view

3.5.3.18

N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine + H2O = L-citrulline + ?

-

2c6z, 3D-view

3.5.3.18

N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine + H2O = L-citrulline + ?

-

2jai, 3D-view

3.5.3.18

Ngamma-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

1h70, 3D-view

3.5.3.18

Ngamma-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2c6z, 3D-view

3.5.3.18

Ngamma-monomethyl-L-arginine + H2O = L-citrulline + methylamine

-

2jai, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = L-citrulline + methanethiol

-

1h70, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = L-citrulline + methanethiol

-

2c6z, 3D-view

3.5.3.18

S-methyl-L-thiocitrulline + H2O = L-citrulline + methanethiol

-

2jai, 3D-view

3.5.3.18

Nomega,Nomega-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

1h70, 3D-view

3.5.3.18

Nomega,Nomega-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2c6z, 3D-view

3.5.3.18

Nomega,Nomega-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2jai, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

1h70, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2c6z, 3D-view

3.5.3.18

Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

-

2jai, 3D-view

3.5.3.6

L-Arg + H2O = L-citrulline + NH3

209455, 209469, 209460, 209466, 209446, 209447, 209454, 209465, 209464, 209468, 209463, 209456, 209457, 209459, 209448, 209458, 209467, 209470, 209471, 209461, 209462, 209449, 209450, 209451, 209452, 209453

1lxy, 3D-view

3.5.3.6

L-arginine + H2O = L-citrulline + NH3

651600

1lxy, 3D-view

3.5.3.6

Nomega-amino-Arg + H2O = L-citrulline + hydrazine

-

1lxy, 3D-view

3.5.3.6

Nomega-methyl-Arg + H2O = L-citrulline + methylamine

-

1lxy, 3D-view

3.5.3.6

Nomega-amino-L-arginine + H2O = L-citrulline + hydrazine

-

1lxy, 3D-view

3.5.3.6

Nomega-methyl-L-arginine + H2O = L-citrulline + methylamine

-

1lxy, 3D-view

3.5.3.6

Nomega-amino-L-arginine + H2O = hydrazine + L-citrulline

-

1lxy, 3D-view

7.4.2.1

ATP + H2O + L-citrulline/out = ADP + phosphate + L-citrulline/in

-

-

7.4.2.1

ATP + H2O + citrulline/out = ADP + phosphate + citrulline/in

-

-

3.5.3.15

3 entries

3.5.3.18

48 entries

3.5.3.6

7 entries

7.4.2.1

2 entries

Inhibitor in Enzyme-catalyzed Reactions (13 results)

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Show Inhibitors (13 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.2

; pH 7.6, 30°C

651026

-

2.3.1.1

10 mM, 75% inhibition

486063

-

2.3.1.35

-

736594

-

2.7.2.2

-

735216

-

2.7.2.8

-

642353, 642356

-

3.5.3.18

competitive

288971

1h70, 3D-view

3.5.3.18

competitive

288971

2c6z, 3D-view

3.5.3.18

competitive

288971

2jai, 3D-view

3.5.3.18

-

670913, 711211

1h70, 3D-view

3.5.3.18

-

670913, 711211

2c6z, 3D-view

3.5.3.18

-

670913, 711211

2jai, 3D-view

3.5.3.18

6 entries

3.5.3.6

-

209455

1lxy, 3D-view

7.4.2.1

1% cell growth, 1% viability of cells

675890

-

3D Structure of Enzyme-Ligand-Complex (PDB) (21 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (21 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.1.3.3

4jqo, 3D-view

2.7.11.22

1ol1, 3D-view

2.7.3.3

4gvy, 3D-view

3.2.1.17

3oe0, 3D-view

3.4.21.36

1qr3, 3D-view

3.4.21.75

6eqv, 3D-view

3.5.3.18

1h70, 3D-view

3.5.3.18

2c6z, 3D-view

3.5.3.18

2jai, 3D-view

3.5.3.18

3 entries

3.5.3.6

1lxy, 3D-view

4.2.1.11

5jlz, 3D-view

4.2.1.11

5nig, 3D-view

4.2.1.11

5ock, 3D-view

5.4.99.5

3zop, 3D-view

5.4.99.5

3zp4, 3D-view

5.4.99.5

3zp7, 3D-view

6.3.4.5

1j1z, 3D-view

6.3.4.5

1j21, 3D-view

6.3.4.5

1k97, 3D-view

6.3.4.5

1kp3, 3D-view

6.3.4.5

2nz2, 3D-view

4.2.1.11

3 entries

5.4.99.5

3 entries

6.3.4.5

5 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.1.3.3

8.1

-

pH 8.0, 37°C

701115

2.1.3.3

90

-

-

485891

2.1.3.3

2 entries

3.5.1.6

0.08

-

pH 8.0, 30°C

720104

K_M Value (8 results)

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Show KM Value (8 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.2

0.026

-

pH 7.6, 30°C

651026

1.4.3.2

21.3

-

fraction II

391785

1.4.3.2

2 entries

1.5.1.11

22

-

L-Met, with pyruvate and NADPH as cosubstrate; with pyruvate and NADPH as cosubstrates

13323

1.5.1.16

17.1

-

-

392094

2.1.3.3

10.4

-

pH 8.0, 37°C

701115

3.5.1.6

9.47

-

pH 8.0, 30°C

720104

6.3.4.5

0.026

-

enzyme form ASSI

1582

6.3.4.5

0.03

-

normal liver

1578

6.3.4.5

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.2

20.6

-

pH 7.6, 30°C; pH 7.6, 30°C

651026

IC₅₀ Value (2 results)

top print hide

Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.3.1.35

30

-

pH 7.5, 37°C

736594

3.5.3.18

3.7

-

pH 7.3, temperature not specified in the publication

711211

References & Links

Literature References (215)

top print hide

Show Reference (215 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1573

-

Purification of argininosuccinate synthetase from cotyledons of germinating peas

1971

Shargool, P.D.

Phytochemistry

10

2029-2032

1574

4355767

Enzymes of arginine and urea synthesis

1973

Ratner, S.

Adv. Enzymol. Relat. Areas Mol. Biol.

39

1-90

1575

5300

Crystallization and some properties of argininosuccinate synthetase from rat liver

1975

Saheki, T.; Kusumi, T.; Takada, S.; Katsunuma, T.; Katunuma, N.

FEBS Lett.

58

314-317

1576

405380

Studies of rat liver argininosuccinate synthetase. I. Physicochemical, catalytic, and immunochemical properties

1977

Saheki, T.; Kusumi, T.; Takada, S.; Katsunuma, T.

J. Biochem.

81

687-696

1577

885853

Biosynthesis of urea. Molecular and regulatory properties of crystalline argininosuccinate synthetase

1977

Rochovansky, O.; Kodowaki, H.; Ratner, S.

J. Biol. Chem.

252

5287-5294

1578

762042

Studies on liver argininosuccinate synthetase in a patient with citrullinemia and in normal subjects

1979

Matsuda, Y.; Tsuji, A.; Katunuma, N.; Hayashi, M.; Takahashi, Y.

J. Biochem.

85

191-195

1579

35347

Yeast argininosuccinate synthetase. Purification, structural and kinetic properties

1979

Hilger, F.; Simon, J.P.; Stalon, V.

Eur. J. Biochem.

94

153-163

1580

447618

Studies on rat liver argininosuccinate synthetase. Inhibition by various amino acids

1979

Takada, S.; Saheki, T.; Igarashi, Y.; Katsunuma, T.

J. Biochem.

85

1309-1314

1581

518841

Isolation and characterization of argininosuccinate synthetase from human liver

1979

O'Brien, W.E.

Biochemistry

18

5353-5356

1582

118168

Studies of rat liver argininosuccinate synthetase. The presence of three forms, and their physicochemical, catalytic, and immunochemical properties

1979

Takada, S.; Kusumi, T.; Saheki, T.; Tsuda, M.; Katsunuma, T.

J. Biochem.

86

1353-1359

1583

6766737

Purification and properties of argininosuccinate synthetase from normal and canavanine-resistant human lymphoblasts

1980

Kimball, M.E.; Jacoby, L.B.

Biochemistry

19

705-709

1584

7446299

Role of argininosuccinate synthetase in the regulation of urea synthesis in the rat and argininosuccinate synthetase-associated metabolic disorder in man

1986

Saheki, T.; Tsuda, M.; Takada, S.; Kusumi, K.; Katsunuma, T.

Adv. Enzyme Regul.

18

221-238

1585

6957859

Argininosuccinate synthetase of bovine liver: chemical and physical properties

1982

Ratner, S.

Proc. Natl. Acad. Sci. USA

79

5197-5199

1586

6885737

Some properties of argininosuccinate synthetase purified from human liver and a comparison with the rat liver enzyme

1983

Saheki, T.; Sase, M.; Nakano, K.; Azuma, F.; Katsunuma, T.

J. Biochem.

93

1531-1537

1587

6605113

Kinetic mechanism of argininosuccinate synthetase

1983

Raushell, F.M.; Seiglie, J.L.

Arch. Biochem. Biophys.

225

979-985

1588

6547814

Nitro analogs of substrates for argininosuccinate synthetase and argininosuccinate lyase

1984

Raushel, F.M.

Arch. Biochem. Biophys.

232

520-525

1589

3863125

Argininosuccinate synthetase: essential role of cysteine and arginine residues in relation to structure and mechanism of ATP activation

1985

Kumar, S.; Lennane, J.; Ratner, S.

Proc. Natl. Acad. Sci. USA

82

6745-6749

1590

9477156

Distribution and co-localization of nitric oxide synthetase and argininosuccinate synthetase in the cat hypothalamus

1997

Isayama, H.; Nakamura, H.; Kanemura, H.; Kobayashi, K.; Emson, P.C.; Kawabuchi, M.; Tashiro, N.

Arch. Histol. Cytol.

60

477-492

1591

7776957

Regulation of argininosuccinate synthetase level by corticosteroid and pancreatic hormones during perinatal period

1995

Demarquoy, J.; Fairand, A.; Gautier, C.; Vaillant, T.

Mol. Cell. Biochem.

143

47-51

1592

7845368

Demonstration of argininosuccinate synthetase activity associated with mitochondrial membrane: characterization and hormonal regulation

1994

Demarquoy, J.; Fairand, A.; Gautier, C.; Vaillant, R.

Mol. Cell. Biochem.

136

145-155

1593

8197477

Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene

1994

Patejunas, G.; Bradley, A.; Beaudet, A.L.; O'Brien, W.E.

Somat. Cell Mol. Genet.

20

55-60

1594

1283210

Immunohistochemical localization of argininosuccinate synthetase in the rat brain in relation to nitric oxide synthase-containg neurons

1992

Arnt-Ramos, L.R.; O'Brien, W.E.; Vincent, S.R.

Neuroscience

51

773-789

1595

2788888

Identification of essential arginine residue(s) for Mg-ATP binding of human argininosuccinate synthetase

1989

Isahiki, Y.; Noda, T.; Kobayashi, K.; Sase, M.; Saheki, T.; Titani, K.

Protein Seq. Data Anal.

2

283-287

1596

1372742

Renal argininosuccinate synthetase: purification, immunohistochemical localization, and elastin-binding property

1992

Wakui, H.; Komatsuda, A.; Itoh, H.; Kobayashi, R.; Nakamoto, Y.; Miura, A.B.

Renal Physiol. Biochem.

15

1-9

1597

8586639

Preparation of recombinant argininosuccinate synthetase and arguininosuccinate lyase: expression of the enzymes in rat tissues

1995

Yu, Y.; Terada, K.; Nagasaki, A.; Takiguchi, M.; Mori, M.

J. Biochem.

117

952-957

1598

8792870

Characterization of human wild-type and mutant argininosuccinate synthetase proteins expressed in bacterial cells

1994

Shaheen, N.; Kobayashi, K.; Terazono, H.; Fukushige, T.; Horiuchi, M.; Saheki, T.

Enzyme Protein

95

251-264

2041

-

Amino acid racemase (Pseudomonas striata)

1971

Soda, K.; Osumi, T.

Methods Enzymol.

17

629-636

2045

-

Purification and characterization of amino acid racemase with very broad substrate specificity from Aeromonas caviae

1987

Inagaki, K.; Tanizawa, K.; Tanaka, H.; Soda, K.

Agric. Biol. Chem.

51

173-180

2047

8320235

A new amino acid racemase with threonine alpha-epimerase activity from Pseudomonas putida: purification and characterization

1993

Lim, Y.H.; Yokoigawa, K.; Esaki, N.; Soda, K.

J. Bacteriol.

175

4213-4217

2165

-

Arginine racemase (Pseudomonas graveolens)

1976

Soda, K.; Yorifuji, T.; Ogata, K.

Methods Enzymol.

17A

341-345

2166

5570439

Arginine racemase of Pseudomonas graveolens. I. Purification, crystallization, and properties

1971

Yorifuji, T.; Ogata, K.

J. Biol. Chem.

246

5085-5092

4748

-

L-Alanine-alpha-ketobutyrate aminotransferase of Pseudomonas sp.

1981

Koide, Y.; Honma, M.; Shimomura, T.

Agric. Biol. Chem.

45

775-776

13323

-

Octopine dehydrogenase of a Vinca rosea crown gall-tumor

1983

Birnberg, P.R.; Rao, S.S.; Lippincott, J.A.

Phytochemistry

22

1345-1355

81203

-

Crystallization and characterization of a novel aminopeptidase from Trichosporon cutaneum

1983

Iwayama, A.; Kimura, T.; Adachi, O.; Ameyama, M.

Agric. Biol. Chem.

47

2483-2493

171967

-

Enzymes of ornithine-arginine metabolism in trypanosomatids of the genus Phytomonas

1987

Camargo Plessmann, E.; Silva, S.; Roitmann, I.; De Souza, W.; Jankevicius, J.V.; Dollet, M.

J. Protozool.

34

439-441

171968

-

L-Citrulline

1985

Eichler, W.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

8

412-418

171969

-

Subcellular distribution and some properties of citrullinase in Euglena gracilis Z

1985

Park, B.S.; Hirotani, A.; Nakano, Y.; Kitaoka, S.

Agric. Biol. Chem.

49

2205-2206

171972

2340108

Regulation of growth and polyamine biosynthesis of the ciliated protozoan Tetrahymena thermophila. Effects of L-arginine metabolites and polyamines

1990

Eichler, W.

Biol. Chem. Hoppe-Seyler

371

273-282

209399

6895223

Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase)

1981

Srivenugopal, K.S.; Adiga, P.R.

J. Biol. Chem.

256

9532-9541

209446

237904

Crystallization and properties of L-arginine deiminase of Pseudomonas putida

1975

Shibatani, T.; Kakimoto, T.; Chibata, I.

J. Biol. Chem.

250

4580-4583

209447

11946203

Crystallization of L-arginine-deiminase from Pseudomonas putida

1971

Kakimoto, T.; Shibatani, T.; Chibata, I.

FEBS Lett.

19

166-168

209448

1262306

Role of arginine deiminase in growth of Mycoplasma hominis

1976

Fenske, J.D.; Kenny, G.E.

J. Bacteriol.

126

501-510

209449

856796

Arginine deiminase from Mycoplasma arthritidis. Evidence for multiple forms

1977

Weickmann, J.L.; Fahrney, D.E.

J. Biol. Chem.

252

2615-2620

209450

697801

Catalysis by arginine deiminase: evidence for a covalent intermediate

1978

Smith, D.W.; Fahrney, D.E.

Biochem. Biophys. Res. Commun.

83

101-106

209451

697802

Arginine deiminase: demonstration of two active sites and possible half-of-the-sites reactivity

1978

Weickmann, J.L.; Himmel, M.E.; Smith, D.W.; Fahrney, D.E.

Biochem. Biophys. Res. Commun.

83

107-113

209452

681335

Arginine deiminase from Mycoplasma arthritidis. Properties of the enzyme from log phase cultures

1978

Weickmann, J.L.; Himmel, M.E.; Squire, P.G.; Fahrney, D.E.

J. Biol. Chem.

253

6010-6015

209453

681336

Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors

1978

Smith, D.W.; Ganaway, R.L.; Fahrney, D.E.

J. Biol. Chem.

253

6016-6020

209454

729806

Subunit and amino acid composition of L-arginine deiminase of Pseudomonas putida

1978

Shibatani, T.; Kakimoto, T.; Chibata, I.

FEBS Lett.

96

389-391

209455

-

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