EC Number   |
Inhibitors |
Structure |
|---|
   1.5.1.6 | N-ethylmaleimide |
1 mM or 10 mM, complete inhibition |
   |
| 1.5.1.6 | p-chloromercuribenzoate |
inhibition reversed by 2-mercaptoethanol |
|
| 1.5.1.6 | propanal |
FDH activity decreases with increasing concentrations, competes with 10-formyltetrahydrofolate for NADP+-dependent oxidation |
|
| 1.5.1.6 | Subtilisin |
cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity |
|
| 1.5.1.6 | tetrahydrofolate |
- |
|
| 1.5.1.6 | tetrahydrofolate |
strong product inhibition by both isomers |
|
| 1.5.1.6 | tetrahydrofolate |
very strong product inhibition |
|
| 1.5.1.6 | tetrahydrofolate |
competitive to 10-formyltetrahydrofolate and non-competitive to NADP+; very strong product inhibition |
|
| 1.5.1.6 | tetrahydrofolate |
potent, competitive product inhibitor |
|
| 1.5.1.6 | tetrahydropteroylhexaglutamate |
1 mol per mol of tetrameric protein, potent product inhibitor: 0.0003 mM, 90% inhibition |
|
