EC Number   |
Inhibitors |
Structure |
|---|
    1.5.1.20 | S-adenosylmethionine |
0.05 mM |
   |
| 1.5.1.20 | S-adenosylmethionine |
inhibits both the reduction of the enzyme-bound flavin by 5-methyltetrahydrofolate and the reoxidation of reduced enzyme by 5,10-methylenetetrahydrofolate |
|
| 1.5.1.20 | S-adenosylmethionine |
- |
|
| 1.5.1.20 | S-adenosylmethionine |
allosteric inhibition |
|
| 1.5.1.20 | S-adenosylmethionine |
inhibitory effect at a physiological concentration, dependent on incubation temperature, binds to an allosteric regulatory site different from catalytic site, reversed by S-adenosylhomocysteine; in vivo feedback-inhibition |
|
| 1.5.1.20 | S-adenosylmethionine |
in vivo feedback-inhibition |
|
| 1.5.1.20 | S-adenosylmethionine |
strong, reversible allosteric inhibition, prevented by S-adenosylhomocysteine |
|
| 1.5.1.20 | S-adenosylmethionine |
SAM, allosteric inhibition by the reaction product. MTHFR phosphorylation, identified on 11 N-terminal residues (16 in total), increases sensitivity to SAM binding and inhibition |
|
| 1.5.1.20 | sinefungin |
- |
|
| 1.5.1.20 | tetrahydrofolate |
- |
|
