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Information on EC - methylenetetrahydrofolate reductase [NAD(P)H]

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IUBMB Comments
A flavoprotein (FAD). The enzyme catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyse a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions. cf. EC, methylenetetrahydrofolate reductase (NADPH); EC, methylenetetrahydrofolate reductase (NADH); and EC, methylenetetrahydrofolate reductase (ferredoxin).
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The enzyme appears in viruses and cellular organisms
respiratory nitrate reductase, 10-methylenetetrahydrofolate reductase, napab, met13, mthfr2, n5,n10-methylenetetrahydrofolate reductase, n5,10-methylenetetrahydrofolate reductase, atmthfr-1, methylenetetrahydrofolate reductase (nadph), 5,10-ch2-h4folate reductase, more
5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+
show the reaction diagram