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EC Number
Inhibitors
Commentary
Structure
1.4.3.13
TNFalpha
TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity
1.4.3.13
TNFalpha
TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and decreases endothelial LOX enzymatic activity
1.4.3.13
tumor necrosis factor-alpha
down-regulates LOX expression
1.4.3.13
tumor necrosis factor-alpha
inhibits LOX mRNA transcription and LOX activity
1.4.3.13
VE-statin/egfl7 protein
interacts with the catalytic domain of lysyl oxidase thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis
1.4.3.13
vitamin B3
-
1.4.3.13
Zn2+
slightly inhibitory
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