1.4.3.13 (1Z)-butanal thiosemicarbazone - 142977 1.4.3.13 (2-chloropyridin-4-yl)methanamine - 220432 1.4.3.13 1-(2-chloropyridin-4-yl)methanamine - 220446 1.4.3.13 1-(2-fluoropyridin-4-yl)methanamine - 220447 1.4.3.13 1-(2-methoxypyridin-4-yl)methanamine - 220449 1.4.3.13 1-(2-phenoxypyridin-4-yl)methanamine - 220450 1.4.3.13 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride - 8759 1.4.3.13 1-(3-fluoropyridin-4-yl)methanamine - 220448 1.4.3.13 1-(4-fluorophenyl)methanamine - 11868 1.4.3.13 1-(4-methoxyphenyl)methanamine - 15412 1.4.3.13 1-(4-nitrophenyl)methanamine - 220435 1.4.3.13 1-(pyridin-4-yl)methanamine - 220442 1.4.3.13 1-(quinolin-4-yl)methanamine - 220444 1.4.3.13 1-([2,3'-bipyridin]-4-yl)methanamine - 220452 1.4.3.13 1-phenylmethanamine - 146907 1.4.3.13 1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine - 220451 1.4.3.13 1-[2-(trifluoromethyl)pyridin-4-yl]methanamine - 220445 1.4.3.13 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride - 10144 1.4.3.13 1-[3-(hydrazinylmethyl)phenyl]methanamine - 220440 1.4.3.13 1-[4-(1,3-thiazol-2-yl)phenyl]methanamine - 220441 1.4.3.13 1-[4-(hydrazinylmethyl)phenyl]methanamine - 220439 1.4.3.13 1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine - 220453 1.4.3.13 2-(pyridin-4-yl)ethan-1-amine - 220443 1.4.3.13 2-Aminopropionitrile i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231 30967 1.4.3.13 2-mercaptoethanol weakly inhibitory 63 1.4.3.13 2-mercaptopyridine-N-oxide fully effective at 200 nM 36350 1.4.3.13 2-mercaptopyridine-N-oxide - 36350 1.4.3.13 2-phenylcyclopropan-1-amine - 220433 1.4.3.13 2-phenylethan-1-amine - 211070 1.4.3.13 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride - 11922 1.4.3.13 3,4-dihydroxybenzoate - 736 1.4.3.13 3-aminopropanenitrile - 36349 1.4.3.13 3-aminopropanenitrile irreversible LOX inhibitor 36349 1.4.3.13 3-aminopropionitrile - 46055 1.4.3.13 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride - 14419 1.4.3.13 4-(aminomethyl)aniline - 220434 1.4.3.13 4-(aminomethyl)benzonitrile - 220436 1.4.3.13 4-deoxypyridoxine pyridoxal analogue, 50% inhibition at 3 mM 7120 1.4.3.13 alpha2-Macroglobulin - 1068 1.4.3.13 ascorbic acid inhibits the purified enzyme in vitro, and the formation of cross-linked collagen 387 1.4.3.13 basic fibroblast growth factor reduces enzyme expression in osteogenic cells 13052 1.4.3.13 beta-aminopropionitrile lathyrogen, organic nitrile group, blocks active site irreversibly and binds covalently 1819 1.4.3.13 beta-aminopropionitrile irreversible 1819 1.4.3.13 beta-aminopropionitrile total inhibition at 1 mM 1819 1.4.3.13 beta-aminopropionitrile - 1819 1.4.3.13 beta-aminopropionitrile irreversible inhibitor 1819 1.4.3.13 beta-aminopropionitrile inhibition of LOXL-1 1819 1.4.3.13 beta-aminopropionitrile selective inhibition of mammalian LOX 1819 1.4.3.13 beta-aminopropionitrile inhibition of active recombinant LOX, LOXL1, and LOXL2, specific 1819 1.4.3.13 beta-aminopropionitrile 80% inhibition at 0.5 mM 1819 1.4.3.13 beta-aminopropionitrile 0.1 mM, irreversible inhibition 1819 1.4.3.13 beta-aminopropionitrile irreversible, competitive inhibitor 1819 1.4.3.13 beta-aminopropionitrile 0.1-0.3 mM, specific inhibitor 1819 1.4.3.13 beta-aminopropionitrile 0.5 mM 1819 1.4.3.13 beta-aminopropionitrile reduces LOX activity and significantly increases MCP-1 secretion in vascular smooth uscle cells 1819 1.4.3.13 beta-aminopropionitrile a specific lysyl oxidase inhibitor, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview 1819 1.4.3.13 beta-aminopropionitrile a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation 1819 1.4.3.13 beta-aminopropionitrile a specific LOX inhibitor 1819 1.4.3.13 beta-aminopropionitrile LOX activity is inhibited by 0.5 mM and above concentrations 1819 1.4.3.13 beta-aminopropionitrile complete inhibition at 0.5 mM 1819 1.4.3.13 beta-aminopropionitrile competitive inhibitor 1819 1.4.3.13 beta-aminopropionitrile 0.4 mM, 20% inhibition 1819 1.4.3.13 cyclohexanone thiosemicarbazone - 143301 1.4.3.13 cycloheximide inhibits incorporation of lysine and Cu2+ into enzyme, blocks activating process 1715 1.4.3.13 cycloheximide - 1715 1.4.3.13 cycloheximide prevents stimulation by transforming growth factor-beta1 1715 1.4.3.13 cyclopentanone thiosemicarbazone - 143302 1.4.3.13 diethyldithiocarbamate - 373 1.4.3.13 Disulfiram a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview 986 1.4.3.13 dithiothreitol - 45 1.4.3.13 erythorbic acid stereoisomer of ascorbic acid 123034 1.4.3.13 glutathione slight inhibition 44 1.4.3.13 heparin - 227 1.4.3.13 homocysteine - 747 1.4.3.13 homocysteine down-regulates LOX mRNA and transcriptional activity 747 1.4.3.13 homocysteine 0.03 mM, up to 50% inhibition 747 1.4.3.13 homocysteine thiolactone - 11477 1.4.3.13 hydroxylamine - 85 1.4.3.13 Isonicotinic acid hydrazide lathyrogen, hydrazide group 2409 1.4.3.13 Isonicotinic acid hydrazide reversible, 61.8% of full activity restored by pyridoxal or 30.1% by pyrroloquinoline-quinone 2409 1.4.3.13 low-density lipoprotein decreases lysyl oxidase mRNA levels in endothelial cells 7377 1.4.3.13 low-density lipoprotein down-regulates LOX expression 7377 1.4.3.13 low-density lipoprotein - 7377 1.4.3.13 methyl 3-(aminomethyl)benzoate - 220438 1.4.3.13 methyl 4-(aminomethyl)benzoate - 220437 1.4.3.13 additional information no inhibition by dehydroascorbic acid 2 1.4.3.13 additional information alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors 2 1.4.3.13 additional information TNF-alpha-stimulated matrix metalloproteinase-9 expression and Erk1/2 activation are both significantly inhibited by LOX-PP 2 1.4.3.13 additional information LOXL4 suppresses the expression of laminins and alpha3 integrin and the activity of matrix metalloproteinase-2 2 1.4.3.13 additional information LOX propeptide expression in Her-2/neu-driven breast cancer cells in culture suppresses Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB activation 2 1.4.3.13 additional information hypercholesterolemia down-regulates LOX expression and activity 2 1.4.3.13 additional information not inhibited by berenil 2 1.4.3.13 N-[2-([2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]amino)ethyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide fully effective at 0.02 mM 143141 1.4.3.13 phenylhydrazine - 398 1.4.3.13 Semicarbazide lathyrogen, ureide group 382 1.4.3.13 Semicarbazide - 382 1.4.3.13 Semicarbazide reversible, 21.2% of full activity restored by pyridoxal or 10% by pyrroloquinoline-quinone 382 1.4.3.13 taurine - 595 1.4.3.13 tert-butyl [2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]carbamate fully effective at 0.002 mM 143176 1.4.3.13 thiram a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview 6965 1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity 3908 1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and decreases endothelial LOX enzymatic activity 3908 1.4.3.13 tumor necrosis factor-alpha down-regulates LOX expression 2910 1.4.3.13 tumor necrosis factor-alpha inhibits LOX mRNA transcription and LOX activity 2910 1.4.3.13 VE-statin/egfl7 protein interacts with the catalytic domain of lysyl oxidase thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis 143711 1.4.3.13 vitamin B3 - 143710 1.4.3.13 Zn2+ slightly inhibitory 14