EC Number   |
Activating Compound |
Reference  |
|---|
    6.3.4.2 | GTP |
required as an allosteric effector to promote glutamine hydrolysis |
648962 |
| 6.3.4.2 | GTP |
required as allosteric effector to promote reaction with glutamine as substrate, GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis |
648963 |
| 6.3.4.2 | GTP |
the binding of GTP to the allosteric site promotes coordination of the phosphorylation of UTP and hydrolysis of glutamine for optimal efficiency in CTP synthesis rather than just acting to increase the rate of glutamine hydrolysis itself |
648964 |
| 6.3.4.2 | GDP |
slight activation |
648982 |
| 6.3.4.2 | GMP |
slight activation |
648982 |
| 6.3.4.2 | GTP |
activates glutamine reaction, no activation of ammonia reaction |
648982 |
| 6.3.4.2 | GTP |
essential activator when glutamine is the nitrogen source |
648985 |
| 6.3.4.2 | 2-mercaptoethanol |
required for optimal activity, above 50 mM increase activity to 221% |
648987 |
| 6.3.4.2 | dithiothreitol |
required for optimal activity, above 50 mM increase activity to 223% mM |
648987 |
| 6.3.4.2 | GTP |
not essential, but acts as activator on the glutamine reaction, optimal activation at 1 mM |
648987 |
