EC Number   |
Activating Compound |
Reference |
|---|
   3.1.3.36 | 1,2-dioctanoylphosphatidylinositol 4-phosphate |
hydrolysis of D-myo-phosphatidylinositol 4,5-bisphosphate and D-myo-phosphatidylinositol 3,4,5-trisphosphate is stimulated up to 100fold |
678188 |
| 3.1.3.36 | Cys |
stimulates |
134812 |
| 3.1.3.36 | dioctanoylphosphatidylserine |
- |
678188 |
| 3.1.3.36 | dithiothreitol |
stimulates |
134812 |
| 3.1.3.36 | IRS4 |
binds and activates the enzyme INP51, acts as a negative regulator for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate contents, IRS4 contains an EPS15 homology domain, interaction analysis |
665564 |
| 3.1.3.36 | mercaptoethanol |
stimulates |
134812 |
| 3.1.3.36 | more |
in contrast to phosphatidylserine SH2 domain containing inositol 5-phosphatase 2 (SHIP2) no stimulation by phosphatidylserine (PtdSer) |
679146 |
| 3.1.3.36 | more |
the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, is rapidly and reversibly activated by strong depolarization of the membrane potential |
716022 |
| 3.1.3.36 | phosphatidylcholine |
vesicles of phosphatidylcholine only stimulate SHIP2 activity by 2fold. This effect is specific for di-C8 and di-C16 fatty acids of D-myo-phosphatidylinositol 3,4,5-trisphosphate as substrate |
679146 |
| 3.1.3.36 | phosphatidylserine |
vesicles of phosphatidylserine (PtdSer) greatly stimulate SHIP2. This effect is specific for di-C8 and di-C16 fatty acids of D-myo-phosphatidylinositol 3,4,5-trisphosphate as substrate |
679146 |
