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Literature summary for 3.1.3.36 extracted from
- Studies on the properties of triphosphoinositide phosphomonoesterase and phosphodiesterase of rabbit iris smooth muscle (1978), Biochim. Biophys. Acta, 527, 159-170.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cys | stimulates | Oryctolagus cuniculus |  |
| dithiothreitol | stimulates | Oryctolagus cuniculus | |
| mercaptoethanol | stimulates | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | 1 mM, 22% inhibition | Oryctolagus cuniculus | |
| GSSG | - |
Oryctolagus cuniculus | |
| PCMB | - |
Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | 77% of the activity is localized in the particulate fraction | Oryctolagus cuniculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 0.1 mM, 32% stimulation | Oryctolagus cuniculus | |
| Mg2+ | 0.1-1 mM, 62% stimulation | Oryctolagus cuniculus | |
| additional information | no requirement for divalent cations | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| iris | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidyl-myo-inositol 4,5-bisphosphate + H2O | - |
Oryctolagus cuniculus | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Oryctolagus cuniculus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 60 | 37°C: optimum, 60°C: about 27% of maximal activity | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
- |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 8.4 | pH 7.2: optimum, pH 8.4: about 65% of maximal activity | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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