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EC Number
Activating Compound
Commentary
Reference
1.1.1.41
ADP
-
286775
,
760834
,
761502
,
762451
1.1.1.41
AMP
-
286749
,
286772
,
654783
1.1.1.41
citrate
-
760834
,
761502
,
762407
,
762451
1.1.1.41
DTT
-
721650
1.1.1.41
NAD+
-
667647
1.1.1.41
citrate
106.29% activity at 1 mM
761311
1.1.1.41
citrate
110% activity at 2 mM
760649
1.1.1.41
AMP
activates ICDH-1
286776
1.1.1.41
ADP
activates. Michaelis-Menten constant for DL-isocitrate is lowered 3.5-fold in the wild-type IDH. The substitution of asparagine for aspartate in alpha-mutant enzyme D181N, beta-subunit mutant enzyme D192N, and gamma-subunit mutant enzyme D190N abolishes this allosteric effect of ADP on Km
685154
1.1.1.41
AMP
activation of the enzyme and reduction of enzyme inhibition by mitochondrial mRNA, highly enhanced by presence of isocitrate, complex formation, overview
654652
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