EC Number   |
Activating Compound |
Reference |
|---|
    6.3.4.2 | more |
activation potency in descending order: GTP = 6-thio-GTP, ITP = guanosine 5'-tetraphosphate, O6-methyl-GTP, 2'-deoxy-GTP, no activation with guanosine, GMP, GDP, 2',3'-dideoxy-GTP, acycloguanosine, and acycloguanosine monophosphate, indicating that the 5'-triphosphate, 2'-OH, and 3'-OH are required for full activation, binding structures and kinetics, overview |
674909 |
| 6.3.4.2 | more |
binding of the substrates ATP and UTP, or the product CTP, promotes oligomerization of CTPS from inactive dimers to active tetramers, Gly142 is critical for nucleotide-dependent oligomerization of CTPS to active tetramers |
690817 |
| 6.3.4.2 | more |
the URA7-encoded enzyme is phosphorylated by protein kinases A and C at Ser424, and these phosphorylations stimulate CTP synthetase activity and increase cellular CTP levels and the utilization of the Kennedy pathway |
694934 |
| 6.3.4.2 | O-methylguanosine 5'-triphosphate |
0 mM guanosine, kact: 2.8/sec, KA: 0.13 mM, Ki: 0.29 mM |
674909 |
| 6.3.4.2 | O6-methyl-GTP |
the GTP analogue is capable of activating Gln-dependent CTP formation |
674909 |
