anaphase-promoting complexGene ontology ID
GO:0005680
Definition
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B
Comment
Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
Synonyms
1. anaphase promoting complex
2. APC
3. cyclosome
References
1. GOC: jh
2. GOC: vw
3. PMID 104657834. PMID 106119695. Wikipedia: Anaphase-promoting complex
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is a part of the parent element
is related to the parent element
derives from the parent element
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