Gene ontology ID
GO:0031545
Definition
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2
Synonyms
1. HIF-type prolyl 4-hydroxylase
2. prolyl 4-hydroxylase
References
1. GOC: mah
2. Reactome: R-HSA-1234165 "Nuclear PHD1,3 hydroxylates proline residues on HIF3A"
3. Reactome: R-HSA-1234166 "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)"
4. Reactome: R-HSA-1234173 "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A"
5. Reactome: R-HSA-1234177 "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A"
6. Reactome: R-HSA-1234179 "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)"
7. Reactome: R-HSA-1234181 "Nuclear PHD1,3 hydroxylates proline residues on HIF1A"
Legend
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is an element of the parent element
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is a part of the parent element
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is related to the parent element
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derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA