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Gene ontology
Version 2014-12-22
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Details for metallocarboxypeptidase activity
3.4.17
Gene ontology ID
GO:0004181
Definition
Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions
References
1. http merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE
2. http merops.sanger.ac.uk/about/glossary.htm#CATTYPE
3. ISBN 0198506732
4. EC 3.4.17
5. Reactome: R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)"
6. Reactome: R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)"
7. Reactome: R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)"
8. Reactome: R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a"
9. Reactome: R-HSA-8866105 "CCPs deglutamylate tubulin"
10. Reactome: R-HSA-8955712 "TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin"
11. Reactome: R-HSA-9023159 "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))"
12. Reactome: R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
nitrogen compound metabolic process is a
organonitrogen compound metabolic process is a
protein metabolic process is a
proteolysis is a
peptidase activity part of
peptidase activity, acting on L-amino acid peptides is a
exopeptidase activity is a
carboxypeptidase activity is a
metallocarboxypeptidase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
aldoxime metabolic process is a
ammonia oxidation is a
ammonium ion metabolic process is a
betaine aldehyde metabolic process is a
nitrogen cycle metabolic process is a
organonitrogen compound metabolic process is a
alkaloid metabolic process is a
amine metabolic process is a
aminoglycan metabolic process is a
N',N'',N'''-triacetylfusarinine C metabolic process is a
nitrile metabolic process is a
primary amino compound metabolic process is a
protein metabolic process is a
amyloid precursor protein metabolic process is a
cytochrome metabolic process is a
cytokine metabolic process is a
insulin metabolic process is a
lipoprotein metabolic process is a
protein activation cascade is a
protein maturation is a
protein modification process is a
proteolysis is a
membrane protein proteolysis is a
peptidase activity part of
isopeptidase activity is a
oligopeptidase activity is a
peptidase activity, acting on D-amino acid peptides is a
peptidase activity, acting on L-amino acid peptides is a
aspartic-type peptidase activity is a
ATP-dependent peptidase activity is a
cysteine-type peptidase activity is a
endopeptidase activity is a
exopeptidase activity is a
aminopeptidase activity is a
carboxypeptidase activity is a
metallocarboxypeptidase activity is a
glutathione S-conjugate carboxypeptidase activity is a
murein tripeptide carboxypeptidase activity is a
zinc D-Ala-D-Ala carboxypeptidase activity is a
serine-type carboxypeptidase activity is a
dipeptidase activity is a
eoxin E4 synthase activity is a
metalloexopeptidase activity is a
omega peptidase activity is a
peptidyl-dipeptidase activity is a
serine-type exopeptidase activity is a
tripeptidase activity is a
tripeptidyl-peptidase activity is a
glutamic-type peptidase activity is a
metallopeptidase activity is a
serine-type peptidase activity is a
threonine-type peptidase activity is a
self proteolysis is a
wybutosine metabolic process is a
reactive nitrogen species metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a