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Gene ontology
Version 2014-12-22
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Details for GTPase activity
Gene ontology ID
GO:0003924
Definition
Catalysis of the reaction: GTP + H2O = GDP + phosphate
Synonyms
1. ARF small monomeric GTPase activity
2. dynamin GTPase activity
3. GTPase activity, coupled
4. heterotrimeric G-protein GTPase activity
5. heterotrimeric G-protein GTPase, alpha-subunit
6. heterotrimeric G-protein GTPase, beta-subunit
7. heterotrimeric G-protein GTPase, gamma-subunit
8. hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
9. protein-synthesizing GTPase activity
10. protein-synthesizing GTPase activity, elongation
11. protein-synthesizing GTPase activity, initiation
12. protein-synthesizing GTPase activity, termination
13. Rab small monomeric GTPase activity
14. Ran small monomeric GTPase activity
15. Ras small monomeric GTPase activity
16. RHEB small monomeric GTPase activity
17. Rho small monomeric GTPase activity
18. Sar small monomeric GTPase activity
19. signal-recognition-particle GTPase activity
20. small monomeric GTPase activity
21. tubulin GTPase activity
References
1. ISBN 0198547684
2. PMID 26832457
3. PMID 27218782
4. Reactome: R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP"
5. Reactome: R-HSA-1458485 "RALA hydrolyzes GTP"
6. Reactome: R-HSA-156923 "Hydrolysis of eEF1A:GTP"
7. Reactome: R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP"
8. Reactome: R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP"
9. Reactome: R-HSA-167415 "G-protein alpha subunit is inactivated"
10. Reactome: R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf"
11. Reactome: R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf"
12. Reactome: R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha"
13. Reactome: R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle"
14. Reactome: R-HSA-203973 "Vesicle budding"
15. Reactome: R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome"
16. Reactome: R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle"
17. Reactome: R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP"
18. Reactome: R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP"
19. Reactome: R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP"
20. Reactome: R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP"
21. Reactome: R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP"
22. Reactome: R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP"
23. Reactome: R-HSA-421835 "trans-Golgi Network Vesicle Scission"
24. Reactome: R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha"
25. Reactome: R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission"
26. Reactome: R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC"
27. Reactome: R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA"
28. Reactome: R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome"
29. Reactome: R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits"
30. Reactome: R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)"
31. Reactome: R-HSA-555065 "Formation of clathrin coated vesicle"
32. Reactome: R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4"
33. Reactome: R-HSA-5638006 "ARL3 hydrolyzes GTP"
34. Reactome: R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity"
35. Reactome: R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments"
36. Reactome: R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP"
37. Reactome: R-HSA-5694527 "Loss of SAR1B GTPase"
38. Reactome: R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity"
39. Reactome: R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP"
40. Reactome: R-HSA-8847534 "RAB43 hydrolyses GTP"
41. Reactome: R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity"
42. Reactome: R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity"
43. Reactome: R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35"
44. Reactome: R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7"
45. Reactome: R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7"
46. Reactome: R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A"
47. Reactome: R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B"
48. Reactome: R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission"
49. Reactome: R-HSA-8981353 "RASA1 stimulates RAS GTPase activity"
50. Reactome: R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated"
51. Reactome: R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated"
52. Reactome: R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated"
53. Reactome: R-HSA-983422 "Disassembly of COPII coated vesicle"
54. RHEA: 19669
Legend
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// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
hydrolase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides is a
pyrophosphatase activity is a
nucleoside-triphosphatase activity is a
ATPase activity is a
ATP-dependent microtubule motor activity is a
GTPase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides is a
5'-acylphosphoadenosine hydrolase activity is a
8-oxo-deoxyadenine diphosphate phosphatase activity is a
8-oxo-dGTP phosphohydrolase activity is a
acylphosphatase activity is a
cyclic-GMP-AMP hydrolase activity is a
dATP phosphohydrolase activity is a
dCTP phosphohydrolase activity is a
dGTP phosphohydrolase activity is a
dihydroneopterin monophosphate phosphatase activity is a
dTTP phosphohydrolase activity is a
dUTP phosphohydrolase activity is a
GTP phosphohydrolase activity is a
ITPase activity is a
nucleoside phosphoacylhydrolase activity is a
phosphocholine hydrolase activity is a
pyrophosphatase activity is a
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity is a
5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity is a
adenosine-tetraphosphatase activity is a
ADP-ribose diphosphatase activity is a
ADP-sugar diphosphatase activity is a
CDP-diacylglycerol diphosphatase activity is a
CDP-glycerol diphosphatase activity is a
CoA pyrophosphatase activity is a
deoxynucleoside-diphosphatase activity is a
diacylglycerol diphosphate phosphatase activity is a
dihydroneopterin triphosphate pyrophosphohydrolase activity is a
diphosphoinositol-polyphosphate diphosphatase activity is a
dolichyldiphosphatase activity is a
endopolyphosphatase activity is a
exopolyphosphatase activity is a
GDP-mannose hydrolase activity is a
guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity is a
inorganic diphosphatase activity is a
inositol bisdiphosphate tetrakisphosphate diphosphatase activity is a
inositol diphosphate pentakisphosphate diphosphatase activity is a
inositol diphosphate tetrakisphosphate diphosphatase activity is a
m7G(5')pppN diphosphatase activity is a
nucleoside-diphosphatase activity is a
nucleoside-triphosphatase activity is a
ATPase activity is a
actin-dependent ATPase activity is a
ATP-dependent microtubule motor activity is a
ATP-dependent microtubule motor activity, minus-end-directed is a
ATP-dependent microtubule motor activity, plus-end-directed is a
ATPase activity, coupled to movement of substances is a
calcium-dependent ATPase activity is a
DNA-dependent ATPase activity is a
helicase activity is a
nucleosome-dependent ATPase activity is a
protein-DNA unloading ATPase activity is a
RNA-dependent ATPase activity is a
tubulin-dependent ATPase activity is a
CTPase activity is a
GTPase activity is a
motor activity is a
thiamin-triphosphatase activity is a
thymidine-triphosphatase activity is a
nucleoside-triphosphate diphosphatase activity is a
nucleotide diphosphatase activity is a
oligosaccharide-diphosphodolichol diphosphatase activity is a
phosphoribosyl-ATP diphosphatase activity is a
RNA pyrophosphohydrolase activity is a
triphosphatase activity is a
UDP-2,3-diacylglucosamine hydrolase activity is a
UDP-sugar diphosphatase activity is a
undecaprenyl-diphosphatase activity is a
RNA NAD-cap (NAD-forming) hydrolase activity is a
RNA NAD-cap (NMN-forming) hydrolase activity is a
trimetaphosphatase activity is a
hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a