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Gene ontology
Version 2014-12-22
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Details for suppression by virus of host ISG15 activity
Gene ontology ID
GO:0039579
Definition
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives
References
1. PMID 11157743
2. PMID 18604270
3. UniProtKB-KW: KW-1095
4. VZ: 723
5. VZ: 723 "Inhibition of host ISG15 by virus"
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