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Literature summary for 7.6.2.1 extracted from

  • Takada, N.; Naito, T.; Inoue, T.; Nakayama, K.; Takatsu, H.; Shin, H.W.
    Phospholipid-flipping activity of P4-ATPase drives membrane curvature (2018), EMBO J., 37, pii: e97705 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E203Q the mutant lacks ATPase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + phosphatidylcholine[side 1] Homo sapiens
-
 ADP + phosphate + phosphatidylcholine[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60312
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylcholine[side 1]
-
 Homo sapiens ADP + phosphate + phosphatidylcholine[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ATP10A
-
 Homo sapiens
P4-ATPase
-
 Homo sapiens
PC-flippase
-
 Homo sapiens
phospholipid flippase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme translocates phospholipids from the exoplasmic/luminal to the cytoplasmic leaflet of biological membranes. The phospholipid-flipping activity of the enzyme can promote membrane deformation Homo sapiens