Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | - |
Mus musculus | - |
- |
chromaffin granule | - |
Mus musculus | 42583 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphatidylserine/in | Mus musculus | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology | ADP + phosphate + phosphatidylserine/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice, two isozymes Atp8a1 and flippase | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
erythroblast | - |
Mus musculus | - |
erythrocyte | - |
Mus musculus | - |
erythroid progenitor cell | - |
Mus musculus | - |
Friend erythroleukemia cell line | - |
Mus musculus | - |
additional information | distribution of isozyme expression in different cells, overview | Mus musculus | - |
reticulocyte | expression analysis of isozymes Atp8a1 and flippase in reticulocytes, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology | Mus musculus | ADP + phosphate + phosphatidylserine/out | - |
? | |
ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry | Mus musculus | ADP + phosphate + phosphatidylserine/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminophospholipid translocase | - |
Mus musculus |
ATP8A1 | - |
Mus musculus |
erythroid ATP-dependent aminophospholipid transporter | - |
Mus musculus |
flippase | - |
Mus musculus |