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Literature summary for 7.4.2.2 extracted from

  • Uemura, S.; Mochizuki, T.; Kurosaka, G.; Hashimoto, T.; Masukawa, Y.; Abe, F.
    Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae (2017), Biochim. Biophys. Acta, 1859, 2076-2085 .
    View publication on PubMed
Search for more literature for 7.4.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a deletion mutant for the high-affinity tryptophan permease Tat2 in Saccharomyces cerevisiae Homo sapiens

Protein Variants

Protein Variants Comment Organism
N81K the mutation completely abrogates tryptophan import without any abnormalities in the expression or localization Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-tryptophan-[L-tryptophan-binding protein][side 1] Homo sapiens
-
 ADP + phosphate + L-tryptophan[side 2] + [L-tryptophan-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-tryptophan-[L-tryptophan-binding protein][side 1]
-
 Homo sapiens ADP + phosphate + L-tryptophan[side 2] + [L-tryptophan-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
high-affinity tryptophan permease
-
 Homo sapiens
MCT10
-
 Homo sapiens
TAT1
-
 Homo sapiens