Any feedback?
Literature summary for 7.4.2.12 extracted from
- TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans (2012), FEMS Microbiol. Lett., 328, 114-121 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-cystathionine | strongly inhibited by DL-cystathionine | Streptococcus mutans |  |
| L-cysteine | moderately inhibited by L-cysteine | Streptococcus mutans | |
| L-djenkolic acid | strongly inhibited by L-djenkolic acid | Streptococcus mutans | |
| additional information | not inhibited by FeSO4, L-arginine, L-glutamine, L-glutamate, L-leucine, and L-methionine | Streptococcus mutans | |
| S-methyl-L-cysteine | moderately inhibited by S-methyl-L-cysteine | Streptococcus mutans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | Streptococcus mutans | - |
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | Streptococcus mutans UA159 | - |
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus mutans | - |
- |
- |
| Streptococcus mutans UA159 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | - |
Streptococcus mutans | ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | - |
Streptococcus mutans UA159 | ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cystine ABC transporter | - |
Streptococcus mutans |
| TcyABC transporter | - |
Streptococcus mutans |
| TcyB | - |
Streptococcus mutans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Streptococcus mutans | the transcriptional regulator TcyR negatively regulates the expression of the enzyme | down |
| Streptococcus mutans | enzyme expression is upregulated under cystine starvation and by the transcriptional activator CysR | up |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
