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Information on EC 7.4.2.12 - ABC-type cystine transporter

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IUBMB Comments
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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L-cystine-[cystine-binding protein][side 1]
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[cystine-binding protein][side 1]
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D-cystine-[cystine-binding protein][side 1]
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[cystine-binding protein][side 1]
Synonyms
cystine ABC importer, cystine ABC transporter, cystine importer, cystine specific transport system, cystine transporting ATPase, cystine-specific ABC transporter, FliY-YecSC, L-cystine ABC transporter, L-cystine transporter, TcyA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + D-cystine-[cystine-binding protein][side 1] = ADP + phosphate + D-cystine[side 2] + [cystine-binding protein][side 1]
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(2)
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ATP + H2O + L-cystine-[cystine-binding protein][side 1] = ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
show the reaction diagram
(1)
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