Literature summary for 7.2.2.1 extracted from

Meng, L.; Meng, F.; Zhang, R.; Zhang, Z.; Dong, P.; Sun, K.; Chen, J.; Zhang, W.; Yan, M.; Li, J.; Abdel-Motaal, H.; Jiang, J.
Characterization of a novel two-component Na+(Li+, K+)/H+ antiporter from Halomonas zhaodongensis (2017), Sci. Rep., 7, 4221 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli KNabc cells	Halomonas zhaodongensis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasmic membrane	-	Halomonas zhaodongensis	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + n Na+[side 1]	Halomonas zhaodongensis	-	ADP + phosphate + n Na+[side 2]	-	?
ATP + H2O + n Na+[side 1]	Halomonas zhaodongensis NEAU-ST10-25T	-	ADP + phosphate + n Na+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Halomonas zhaodongensis	-	-	-
Halomonas zhaodongensis NEAU-ST10-25T	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
A-Sepharose column chromatography	Halomonas zhaodongensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + n K+[side 1]	-	Halomonas zhaodongensis	ADP + phosphate + n K+[side 2]	-	?
ATP + H2O + n K+[side 1]	-	Halomonas zhaodongensis NEAU-ST10-25T	ADP + phosphate + n K+[side 2]	-	?
ATP + H2O + n Li+[side 1]	-	Halomonas zhaodongensis	ADP + phosphate + n Li+[side 2]	-	?
ATP + H2O + n Li+[side 1]	-	Halomonas zhaodongensis NEAU-ST10-25T	ADP + phosphate + n Li+[side 2]	-	?
ATP + H2O + n Na+[side 1]	-	Halomonas zhaodongensis	ADP + phosphate + n Na+[side 2]	-	?
ATP + H2O + n Na+[side 1]	-	Halomonas zhaodongensis NEAU-ST10-25T	ADP + phosphate + n Na+[side 2]	-	?

Subunits

Subunits	Comment	Organism
heterodimer	1 * 25000 + 1 * 22000, SDS-PAGE	Halomonas zhaodongensis

Synonyms

Synonyms	Comment	Organism
Na+(Li+, K+)/H+ antiporter	-	Halomonas zhaodongensis
UmpAB	-	Halomonas zhaodongensis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9	-	-	Halomonas zhaodongensis

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.5	9.5	the enzyme exhibits Na+/H+ and K+/H+ antiport activity at a wide range of pH 7.0-9.5, but Li+/H+ antiport activity at pH between 7.5 and 9.5	Halomonas zhaodongensis

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Release 2023.1 (January 2023)