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Literature summary for 7.1.1.2 extracted from

  • Duval, R.A.; Lewin, G.; Peris, E.; Chahboune, N.; Garofano, A.; Droese, S.; Cortes, D.; Brandt, U.; Hocquemiller, R.
    Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins (2006), Biochemistry, 45, 2721-2728.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
1-Geranyl-2-methylbenzimidazole 0.001 mM, 87% inhibition Bos taurus
2-n-decyl-4-quinazolinylamine 0.001 mM, 73% inhibition Bos taurus
37-methoxyquinoxalinone IC50: 10 nM Bos taurus
39-pyridopyrazinone IC50: 17 nM Bos taurus
benzimidazole 0.001 mM, 72% inhibition Bos taurus
benzoxazinone 0.001 mM, 76% inhibition Bos taurus
imidazole 0.001 mM, 75% inhibition Bos taurus
Myxothiazol IC50: 170 nM Bos taurus
quinoxalinone 0.001 mM, 79% inhibition Bos taurus
rolliniastatin-2 0.001 mM, 92% inhibition Bos taurus
rotenone 0.001 mM, 90% inhibition Bos taurus
squamocin 0.001 mM, 88% inhibition Bos taurus
squamocin-quinoxalinone
-
 Bos taurus
squamocin-triazine
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + n-decylubiquinone + H+
-
 Bos taurus NAD+ + n-decylubiquinol
-
 ?
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Bos taurus
NADH-ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 IC50: 10 nM Bos taurus 37-methoxyquinoxalinone
0.000017
-
 IC50: 17 nM Bos taurus 39-pyridopyrazinone
0.00017
-
 IC50: 170 nM Bos taurus Myxothiazol