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Literature summary for 6.3.4.14 extracted from
- Functional interaction of Azotobacter vinelandii cytoplasmic cyclophilin with the biotin carboxylase subunit of acetyl-CoA carboxylase (2012), Biochem. Biophys. Res. Commun., 424, 736-739.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cyclophilin | cyclophilin stimulates the ATP hydrolysis activity of the enzyme (8fold stimulation of activity at 10fold molar excess over the enzyme) | Azotobacter vinelandii |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Azotobacter vinelandii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + biotin-carboxyl-carrier protein + HCO3- | Azotobacter vinelandii | - |
ADP + phosphate + carboxybiotin-carboxyl-carrier protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Azotobacter vinelandii | C1DLJ7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Azotobacter vinelandii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + biotin-carboxyl-carrier protein + HCO3- | - |
Azotobacter vinelandii | ADP + phosphate + carboxybiotin-carboxyl-carrier protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AccC | biotin carboxylase subunit of acetyl-CoA carboxylase | Azotobacter vinelandii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Azotobacter vinelandii | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme shows inhibitory effect of on the peptidyl-prolyl cis/trans isomerase activity of cyclophilin (49% inhibition at 40fold molar excess over ppiB). Conversely, cyclophilin stimulates the ATP hydrolysis activity of the enzyme | Azotobacter vinelandii |
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