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Information on EC 6.3.4.14 - biotin carboxylase

for references in articles please use BRENDA:EC6.3.4.14

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IUBMB Comments

This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15, biotin—[biotin carboxyl-carrier protein] ligase. In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria). Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyses the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2, acetyl-CoA carboxylase).

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
biotin carboxylase, accbc, pc-beta, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle, biotin-carboxyl carrier protein assembly, glyoxylate assimilation