Literature summary for 6.3.2.2 extracted from

Huang, J.Y.; Chuang, J.I.
Fibroblast growth factor 9 upregulates heme oxygenase-1 and gamma-glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity (2010), Free Radic. Biol. Med., 49, 1099-1108.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-buthionine-(S,R)-sulfoximine	cotreatment with L-buthionine-(S,R)-sulfoximine, 1-methyl-4-phenylpyridinium and fibroblast growth factor 9 inhibits increased neuron viability compared to the group treated with 1-methyl-4-phenylpyridinium and fibroblast growth factor 9, to levels comparable to those of the 1-methyl-4-phenylpyridinium-treated group	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	primary astrocyte	Rattus norvegicus	-
neuron	primary cortical neuron	Rattus norvegicus	-

Expression

Organism	Comment	Expression
Rattus norvegicus	fibroblast growth factor 9 treatment alone induces a decrease in hydrogen peroxide level, an increase in glutathione content, and an upregulation of gamma-glutamylcysteine synthetase and heme oxygenase 1 expression in primary cortical neurons but not in astrocytes. Simultaneous treatmentwith fibroblast growth factor 9 and 1-methyl-4-phenylpyridinium prevents 1-methyl-4-phenylpyridinium-induced neuron death and H2O2 overproduction but does not affect the fibroblast growth factor 9-increased gamma-GCS and HO-1 protein expression	up

General Information

General Information	Comment	Organism
physiological function	fibroblast growth factor 9 upregulates gamma-GCS and HO-1 expression to protect cortical and dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced oxidative insult. Inhibition of gamma-GCS or HO-1 prevents the inhibitory effect of fibroblast growth factor 9 on 1-methyl-4-phenylpyridinium-induced H2O2 production and death in mesencephalic dopaminergic and cortical neurons. In the absence of 1-methyl-4-phenylpyridinium, the fibroblast growth factor 9-induced H2O2 reduction is blocked by HO-1 inhibitors, but not by gamma-GCS inhibitors	Rattus norvegicus

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Release 2023.1 (January 2023)