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Literature summary for 6.2.1.63 extracted from

  • Balado, M.; Osorio, C.R.; Lemos, M.L.
    A gene cluster involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore produced by Vibrio anguillarum (2006), Microbiology, 152, 3517-3528 .
    View publication on PubMed
Search for more literature for 6.2.1.63

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-arginine + holo-[L-arginyl-carrier protein] Vibrio anguillarum serovar O2 the enzyme is involved in the biosynthesis of vanchrobactin AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein]
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Organism

Organism UniProt Comment Textmining
Vibrio anguillarum serovar O2 Q0E7C4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(L-arginyl)adenylate + holo-[L-arginyl-carrier protein] the adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl) adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain Vibrio anguillarum serovar O2 diphosphate + (L-arginyl)adenylate
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ATP + L-arginine the adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl) adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain Vibrio anguillarum serovar O2 diphosphate + (L-arginyl)adenylate
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ATP + L-arginine + holo-[L-arginyl-carrier protein] the enzyme is involved in the biosynthesis of vanchrobactin Vibrio anguillarum serovar O2 AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein]
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ATP + L-arginine + holo-[L-arginyl-carrier protein] overall reaction. The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl) adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain Vibrio anguillarum serovar O2 AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein]
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Synonyms

Synonyms Comment Organism
vabF
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 Vibrio anguillarum serovar O2

General Information

General Information Comment Organism
malfunction significant production of 2,3-dihydroxybenzoic acid (about 50% of that produced by the wild-type) is detected om in vabF-null mutant Vibrio anguillarum serovar O2
physiological function the enzyme is involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore Vibrio anguillarum serovar O2