Information on EC 6.2.1.63 - L-arginine-[L-arginyl-carrier protein] ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.63 L-arginine-[L-arginyl-carrier protein] ligase
IUBMB Comments
The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.
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The expected taxonomic range for this enzyme is: Vibrio anguillarum serovar O2
Reaction Schemes
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holo-[L-arginyl-carrier protein]
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L-arginyl-[L-arginyl-carrier protein]
(L-arginyl)adenylate
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holo-[L-arginyl-carrier protein]
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L-arginyl-[L-arginyl-carrier protein]
Synonyms
vabF, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(L-arginyl)adenylate + holo-[L-arginyl-carrier protein] = AMP + L-arginyl-[L-arginyl-carrier protein]
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(1b)
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ATP + L-arginine + holo-[L-arginyl-carrier protein] = AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein]
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overall reaction
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ATP + L-arginine = diphosphate + (L-arginyl)adenylate
show the reaction diagram
(1a)
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