Literature summary for 6.1.2.1 extracted from

Sova, M.; Cadez, G.; Turk, S.; Majce, V.; Polanc, S.; Batson, S.; Lloyd, A.J.; Roper, D.I.; Fishwick, C.W.; Gobec, S.
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) (2009), Bioorg. Med. Chem. Lett., 19, 1376-1379.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate	75% inhibition at 0.5 mM	Enterococcus faecium
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl phenyl hydrogen phosphate	65% inhibition at 0.5 mM	Enterococcus faecium
1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate	83% inhibition at 0.5 mM	Enterococcus faecium

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecium	-	isoform VanA	-

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Release 2023.1 (January 2023)