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Information on EC 6.1.2.1 - D-alanine-(R)-lactate ligase

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EC Tree
     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.2 acid-alcohol ligases (ester synthases)
                6.1.2.1 D-alanine-(R)-lactate ligase
IUBMB Comments
The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
D-Ala-D-Lac ligase, D-Ala:D-Lac ligase, D-alanine-D-lactate ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-alanine:D-lactate ligase, D-alanyl-D-lactate ligase, depsipeptide ligase, VanA, VanB, VanD, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate
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PATHWAY SOURCE
PATHWAYS
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