Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-anhydro-2-bromo-2,3,5-trideoxy-1-(1-fluoroethenyl)-3-methyl-5-([3-[(4-oxo-1,4-dihydroquinolin-2-yl)amino]propyl]amino)-1-thiopentitol | - |
Plasmodium falciparum | |
2-([2-[([2-[(2-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol | - |
Plasmodium falciparum | |
2-([2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol | - |
Plasmodium falciparum | |
2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethan-1-ol | - |
Plasmodium falciparum | |
2-[[2-([[2-(benzyloxy)naphthalen-1-yl]methyl]amino)ethyl]amino]ethan-1-ol | - |
Plasmodium falciparum | |
3-[[(4-chloronaphthalen-1-yl)oxy]methyl]piperidine | - |
Plasmodium falciparum | |
4-(1H-benzimidazol-2-yl)-N-[(2-chloro-6-fluorophenyl)methyl]aniline | - |
Plasmodium falciparum | |
4-(1H-benzimidazol-2-yl)-N-[(3-chlorophenyl)methyl]aniline | - |
Plasmodium falciparum | |
4-(1H-benzimidazol-2-yl)-N-[(4-chlorophenyl)methyl]aniline | - |
Plasmodium falciparum | |
5-([3-[(6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl)amino]propyl]amino)thieno[3,2-b]pyridin-7(4H)-one | - |
Plasmodium falciparum | |
anisomycin | - |
Plasmodium falciparum | |
REP3123 | - |
Plasmodium falciparum | |
REP8839 | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apicoplast | - |
Plasmodium falciparum | 20011 | - |
cytoplasm | - |
Plasmodium falciparum | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + tRNAMet | Plasmodium falciparum | - |
AMP + diphosphate + L-methionyl-tRNAMet | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + tRNAMet | - |
Plasmodium falciparum | AMP + diphosphate + L-methionyl-tRNAMet | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionyl-tRNA synthetase | - |
Plasmodium falciparum |
MRSapi | isoform | Plasmodium falciparum |
MRScyt | isoform | Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000144 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 5-([3-[(6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl)amino]propyl]amino)thieno[3,2-b]pyridin-7(4H)-one | |
0.000146 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | REP3123 | |
0.000155 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 1,4-anhydro-2-bromo-2,3,5-trideoxy-1-(1-fluoroethenyl)-3-methyl-5-([3-[(4-oxo-1,4-dihydroquinolin-2-yl)amino]propyl]amino)-1-thiopentitol | |
0.000177 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 4-(1H-benzimidazol-2-yl)-N-[(2-chloro-6-fluorophenyl)methyl]aniline | |
0.000281 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | REP8839 | |
0.000293 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 2-([2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol | |
0.000303 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 3-[[(4-chloronaphthalen-1-yl)oxy]methyl]piperidine | |
0.074 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | anisomycin |