Literature summary for 5.6.2.2 extracted from

Nielsen, C.F.; Huttner, D.; Bizard, A.H.; Hirano, S.; Li, T.N.; Palmai-Pallag, T.; Bjerregaard, V.A.; Liu, Y.; Nigg, E.A.; Wang, L.H.; Hickson, I.D.
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis (2015), Nat. Commun., 6, 8962 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
PICh protein	purified PICH protein strongly stimulates the catalytic decatenation activity of the enzyme in vitro	Gallus gallus

Inhibitors

Inhibitors	Comment	Organism	Structure
ICRF-193	-	Gallus gallus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	10 mM used in assay conditions	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DT-40 cell	-	Gallus gallus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + catenated DNA	-	Gallus gallus	ADP + phosphate + decatenated DNA	-	?

Synonyms

Synonyms	Comment	Organism
Topo IIalpha	-	Gallus gallus
topoisomerase IIalpha	-	Gallus gallus

General Information

General Information	Comment	Organism
physiological function	PICh protein and the enzyme cooperate to prevent chromosome missegregation events in mitosis	Gallus gallus

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Release 2023.1 (January 2023)