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Literature summary for 5.6.2.2 extracted from

  • Heng, X.; Le, W.D.
    The function of DNA topoisomerase IIbeta in neuronal development (2010), Neurosci. Bull., 26, 411-416.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
gene Top IIbeta is located to chromosome 3p24 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information IIbeta knockout embryos show downregulated expression of genes encoding proteins involved in neuron migration, e.g. Reln, Dab1, Sst and Robo1, cell adhesion, e.g. Catna2, Cdh4, Cdh8, Nell2 and Alcam, voltage-gated calcium channel activity, e.g. Cacna2d1 and Cacna2d3, synaptic transmission, e.g. Syt1, and cytoskeleton formation, e.g., neurofilament. The expression of some transcription factors, e.g. Myt1l, Ebf1 and Mef2c, implicated in various differentiation pathways, is also downregulated in the mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
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 Mus musculus 785
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chromatin
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 Homo sapiens 785
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cytoplasm DNA Top IIbeta is localized in the nucleolus during interphase, and in the cytoplasm during mitosis Mus musculus 5737
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cytoplasm DNA Top IIbeta is localized in the nucleolus during interphase, and in the cytoplasm during mitosis Homo sapiens 5737
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nucleolus DNA Top IIbeta is localized in the nucleolus during interphase, and in the cytoplasm during mitosis Mus musculus 5730
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nucleolus DNA Top IIbeta is localized in the nucleolus during interphase, and in the cytoplasm during mitosis Homo sapiens 5730
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nucleoplasm in the brain at embryonic stage Mus musculus 5654
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nucleoplasm in the brain at embryonic stage Homo sapiens 5654
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isozyme IIbeta
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Mus musculus
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 isozyme IIbeta
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Source Tissue

Source Tissue Comment Organism Textmining
brain spatio-temporal expression pattern of DNA Top IIbeta, overview Mus musculus
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brain spatio-temporal expression pattern of DNA Top IIbeta, overview Homo sapiens
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additional information Top IIbeta has a distinct cellular localization pattern and a cell cycle expression profile. Its activity is constant throughout the cell cycle. The IIbeta isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells Mus musculus
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additional information Top IIbeta has a distinct cellular localization pattern and a cell cycle expression profile. Its activity is constant throughout the cell cycle. The IIbeta isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells Homo sapiens
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neuron Top IIbeta is highly expressed in differentiating cerebellar neurons Mus musculus
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neuron Top IIbeta is highly expressed in differentiating cerebellar neurons Homo sapiens
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P-388 cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
DNA Top IIbeta
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 Mus musculus
DNA Top IIbeta
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 Homo sapiens
DNA topoisomerase IIbeta
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 Mus musculus
DNA topoisomerase IIbeta
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the migration of postmitotic cortical neurons is affected in Top IIbeta mutant embryos Mus musculus
additional information cortical neurons in Top IIbeta knockout mice show downregulated expression levels of certain neuronal genes, i.e. Robo1, catenin alpha 2, cadherin 8, and synaptotagmin Mus musculus
physiological function the enzymatic activity of the IIbeta isoform is involved in the early stage of neuronal gene expression, probably through decondensation of the chromatin structure of the gene-containing region. The signal-dependent activation of gene transcription by nuclear receptors and other classes of DNA-binding transcription factors, including activating protein 1, requires DNA Top IIbeta-dependent, transient, site-specific dsDNA break formation, with subsequent activation of PARP-1 enzymatic function, which causes local changes of chromatin architecture. Top IIbeta controls and alters the topologic states of DNA during transcription, and is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. Significant role of Top IIbeta in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division, role of DNA Top IIbeta in axon guidance, overview Mus musculus
physiological function the enzymatic activity of the IIbeta isoform is involved in the early stage of neuronal gene expression, probably through decondensation of the chromatin structure of the gene-containing region. The signal-dependent activation of gene transcription by nuclear receptors and other classes of DNA-binding transcription factors, including activating protein 1, requires DNA Top IIbeta-dependent, transient, site-specific dsDNA break formation, with subsequent activation of PARP-1 enzymatic function, which causes local changes of chromatin architecture. Top IIbeta controls and alters the topologic states of DNA during transcription, and is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. Significant role of Top IIbeta in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division, role of DNA Top IIbeta in axon guidance, overview Homo sapiens