Literature summary for 5.6.2.2 extracted from

Ahn, G.; Schifano-Faux, N.; Goossens, J.F.; Baldeyrou, B.; Couture, A.; Grandclaudon, P.; Lansiaux, A.; Ryckebusch, A.
Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones (2011), Bioorg. Med. Chem. Lett., 21, 2259-2263.

Search for more literature for 5.6.2.2

Inhibitors

Inhibitors	Comment	Organism	Structure
6-[2-(dimethylamino)ethyl]-8-hydroxy-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	moderate inhibition	Homo sapiens
6-[2-(dimethylamino)ethyl]-8-[3-(dimethylamino)propoxy]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	strong inhibition	Homo sapiens
6-[3-(dimethylamino)propyl]-8-hydroxy-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	moderate inhibition	Homo sapiens
6-[4-(dimethylamino)butyl]-8-[2-(dimethylamino)ethoxy]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	weak inhibition	Homo sapiens
6-[4-(dimethylamino)butyl]-8-[3-(dimethylamino)propoxy]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	weak inhibition	Homo sapiens
8-[2-(dimethylamino)ethoxy]-6-[2-(dimethylamino)ethyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	very strong inhibition	Homo sapiens
8-[3-(dimethylamino)propoxy]-6-[3-(dimethylamino)propyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione	strong inhibition	Homo sapiens
etoposide	very strong inhibition	Homo sapiens
additional information	synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
topo II	-	Homo sapiens
Topoisomerase II	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)