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Literature summary for 5.6.2.2 extracted from

  • Neukam, K.; Pastor, N.; Cortes, F.
    Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells (2008), Mutat. Res., 654, 8-12.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(+)-catechin
-
 Cricetulus griseus
(-)-epicatechin
-
 Cricetulus griseus
(-)-epigallocatechin
-
 Cricetulus griseus
(-)-epigallocatechin-3-gallate
-
 Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-AA8 cell
-
 Cricetulus griseus
-
ovary
-
 Cricetulus griseus
-

Synonyms

Synonyms Comment Organism
topo II
-
 Cricetulus griseus
Topoisomerase II
-
 Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cricetulus griseus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0372
-
-
 Cricetulus griseus (-)-epicatechin
0.046
-
-
 Cricetulus griseus (+)-catechin
3.61
-
-
 Cricetulus griseus (-)-epigallocatechin
3.78
-
-
 Cricetulus griseus (-)-epigallocatechin-3-gallate