Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-methoxybenzyl)-1H-[1,2,3]triazolo[4,5-g]-phthalazine-4,9-dione | - |
Homo sapiens | |
1-ethyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1-iso-butyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1-iso-propyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1-methyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1-n-butyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1-n-propyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
1H-[1,2,3]triazolo[4,5,-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-ethyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-iso-butyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-iso-propyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-methyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-n-butyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
2-n-propyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | - |
Homo sapiens | |
doxorubicin | - |
Homo sapiens | |
etoposide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HCT-15 cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
HT-1080 cell | - |
Homo sapiens | - |
SK-MEL-2 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
SNU-638 cell | - |
Homo sapiens | - |
XF-498 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
topo II | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0194 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-iso-butyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | |
0.0286 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-(4-methoxybenzyl)-1H-[1,2,3]triazolo[4,5-g]-phthalazine-4,9-dione | |
0.0298 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-iso-butyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0333 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-iso-propyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.039 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-methyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0432 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-n-butyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0444 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-n-propyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | |
0.049 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-n-propyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0528 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1H-[1,2,3]triazolo[4,5,-g]phthalazine-4,9-dione | |
0.0545 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-iso-propyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0556 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-methyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0556 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-ethyl-1H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0615 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-ethyl-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione | |
0.0648 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 2-n-butyl-2H-[1,2,3] triazolo[4,5-g]phthalazine-4,9-dione | |
0.0929 | - |
in 50 mM Tris-HCl, pH 8, 120 mM KCl, 10 mM MgCl2, 0.5 mM ATP, 0.5 mM dithiothreitol, 0.03 mg/ml bovine serum albumin, at 37°C | Homo sapiens | etoposide |