Literature summary for 5.6.2.2 extracted from

Flamm, R.K.; Vojtko, C.; Chu, D.T.; Li, Q.; Beyer, J.; Hensey, D.; Ramer, N.; Clement, J.J.; Tanaka, S.K.
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor (1995), Antimicrob. Agents Chemother., 39, 964-970.

Inhibitors

Inhibitors	Comment	Organism
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Acinetobacter calcoaceticus
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Bacteroides fragilis
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Bacteroides thetaiotaomicron
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml	Citrobacter freundii
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Citrobacter spp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml	Clostridioides difficile
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Clostridium perfringens
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml	Corynebacterium sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml	Enterococcus faecium
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Enterococcus sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000008 mg/ml	Escherichia coli
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000003 mg/ml	Haemophilus influenzae
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Klebsiella sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Legionella sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Listeria monocytogenes
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml	Moraxella catarrhalis
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Morganella morganii
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.016 mg/ml	Mycobacterium avium
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml	Neisseria gonorrhoeae
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Peptostreptococcus sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml	Prevotella bivia
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Proteus mirabilis
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Providencia rettgeri
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Providencia stuartii
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml	Pseudomonas aeruginosa
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml	Salmonella sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml	Serratia marcescens
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative	Shigella sp.
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml for strain CiproS, 0.00025 mg/ml for strain CiproR, and 0.001 mg/ml for the methicillin-resistant strain	Staphylococcus aureus
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml for the wild-type and 0.00025 mg/ml for the methicillin-resistant strain	Staphylococcus epidermidis
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml	Streptococcus agalactiae
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml for the wild-type strain and for the strain Pen I/R	Streptococcus pneumoniae
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Streptococcus pyogenes
ABT-719	i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml	Streptococcus viridans
Ciprofloxacin	MIC90 is 0.0005 mg/ml	Acinetobacter calcoaceticus
Ciprofloxacin	MIC90 is 0.016 mg/ml	Bacteroides fragilis
Ciprofloxacin	MIC90 is 0.032 mg/ml	Bacteroides thetaiotaomicron
Ciprofloxacin	MIC90 is 0.00012 mg/ml	Citrobacter freundii
Ciprofloxacin	MIC90 is 0.00003 mg/ml	Citrobacter spp.
Ciprofloxacin	MIC90 is 0.016 mg/ml	Clostridioides difficile
Ciprofloxacin	MIC90 is 0.0005 mg/ml	Clostridium perfringens
Ciprofloxacin	MIC90 is 0.002 mg/ml	Corynebacterium sp.
Ciprofloxacin	MIC90 is 0.002 mg/ml	Enterococcus faecium
Ciprofloxacin	MIC90 is 0.064 mg/ml	Enterococcus sp.
Ciprofloxacin	MIC90 is 0.000015 mg/ml	Escherichia coli
Ciprofloxacin	MIC90 is 0.00003 mg/ml	Haemophilus influenzae
Ciprofloxacin	MIC90 is 0.00006 mg/ml	Klebsiella sp.
Ciprofloxacin	MIC90 is 0.00025 mg/ml	Legionella sp.
Ciprofloxacin	MIC90 is 0.002 mg/ml	Listeria monocytogenes
Ciprofloxacin	MIC90 is 0.00003 mg/ml	Moraxella catarrhalis
Ciprofloxacin	MIC90 is 0.00003 mg/ml	Morganella morganii
Ciprofloxacin	MIC90 is 0.016 mg/ml	Mycobacterium avium
Ciprofloxacin	MIC90 is 0.00006 mg/ml	Neisseria gonorrhoeae
Ciprofloxacin	MIC90 is 0.004 mg/ml	Peptostreptococcus sp.
Ciprofloxacin	MIC90 is 0.016 mg/ml	Prevotella bivia
Ciprofloxacin	MIC90 is 0.00006 mg/ml	Proteus mirabilis
Ciprofloxacin	MIC90 is 0.00006 mg/ml	Providencia rettgeri
Ciprofloxacin	MIC90 is 0.00012 mg/ml	Providencia stuartii
Ciprofloxacin	MIC90 is 0.0005 mg/ml	Pseudomonas aeruginosa
Ciprofloxacin	MIC90 is 0.00006 mg/ml	Salmonella sp.
Ciprofloxacin	MIC90 is 0.00025 mg/ml	Serratia marcescens
Ciprofloxacin	-	Shigella sp.
Ciprofloxacin	MIC90 is 0.0005 mg/ml for strain CiproS, 0.064 mg/ml for strain CiproR, and 0.128 mg/ml for the methicillin-resistant strain	Staphylococcus aureus
Ciprofloxacin	MIC90 is 0.00025 mg/ml for the wild-type and 0.032 mg/ml for the methicillin-resistant strain	Staphylococcus epidermidis
Ciprofloxacin	MIC90 is 0.002 mg/ml	Streptococcus agalactiae
Ciprofloxacin	MIC90 is 0.002 mg/ml for the wild-type strain and for the strain Pen I/R	Streptococcus pneumoniae
Ciprofloxacin	MIC90 is 0.002 mg/ml	Streptococcus pyogenes
Ciprofloxacin	MIC90 is 0.002 mg/ml	Streptococcus viridans
clinafloxacin	MIC90 is 0.00006 mg/ml	Acinetobacter calcoaceticus
clinafloxacin	MIC90 is 0.00025 mg/ml	Bacteroides fragilis
clinafloxacin	MIC90 is 0.0005 mg/ml	Bacteroides thetaiotaomicron
clinafloxacin	MIC90 is 0.00012 mg/ml	Citrobacter freundii
clinafloxacin	MIC90 is 0.00003 mg/ml	Citrobacter spp.
clinafloxacin	MIC90 is 0.00025 mg/ml	Clostridioides difficile
clinafloxacin	MIC90 is 0.00025 mg/ml	Clostridium perfringens
clinafloxacin	MIC90 is 0.00012 mg/ml	Corynebacterium sp.
clinafloxacin	MIC90 is 0.00025 mg/ml	Enterococcus faecium
clinafloxacin	MIC90 is 0.002 mg/ml	Enterococcus sp.
clinafloxacin	MIC90 is 0.000015 mg/ml	Escherichia coli
clinafloxacin	MIC90 is 0.000003 mg/ml	Haemophilus influenzae
clinafloxacin	MIC90 is 0.00003 mg/ml	Klebsiella sp.
clinafloxacin	MIC90 is 0.00012 mg/ml	Legionella sp.
clinafloxacin	MIC90 is 0.00012 mg/ml	Listeria monocytogenes
clinafloxacin	MIC90 is 0.000015 mg/ml	Moraxella catarrhalis
clinafloxacin	MIC90 is 0.00003 mg/ml	Morganella morganii
clinafloxacin	MIC90 is 0.064 mg/ml	Mycobacterium avium
clinafloxacin	MIC90 is 0.000015 mg/ml	Neisseria gonorrhoeae
clinafloxacin	MIC90 is 0.00025 mg/ml	Peptostreptococcus sp.
clinafloxacin	MIC90 is 0.00025 mg/ml	Prevotella bivia
clinafloxacin	MIC90 is 0.00003 mg/ml	Proteus mirabilis
clinafloxacin	MIC90 is 0.00003 mg/ml	Providencia rettgeri
clinafloxacin	MIC90 is 0.00003 mg/ml	Providencia stuartii
clinafloxacin	MIC90 is 0.00025 mg/ml	Pseudomonas aeruginosa
clinafloxacin	MIC90 is 0.00003 mg/ml	Salmonella sp.
clinafloxacin	MIC90 is 0.00006 mg/ml	Serratia marcescens
clinafloxacin	-	Shigella sp.
clinafloxacin	MIC90 is 0.00003 mg/ml for strain CiproS, 0.001 mg/ml for strain CiproR, and 0.001 mg/ml for the methicillin-resistant strain	Staphylococcus aureus
clinafloxacin	MIC90 is 0.00003 mg/ml for the wild-type and 0.001 mg/ml for the methicillin-resistant strain	Staphylococcus epidermidis
clinafloxacin	MIC90 is 0.00025 mg/ml	Streptococcus agalactiae
clinafloxacin	MIC90 is 0.00012 mg/ml for the wild-type strain and 0.00025 mg/ml for the strain Pen I/R	Streptococcus pneumoniae
clinafloxacin	MIC90 is 0.00006 mg/ml	Streptococcus pyogenes
clinafloxacin	MIC90 is 0.00006 mg/ml	Streptococcus viridans
additional information	ciprofloxacin-resistant strain shows increased MIC90 values for the inhibitors compared to the wild-type strains	Pseudomonas aeruginosa
sparfloxacin	MIC90 is 0.00006 mg/ml	Acinetobacter calcoaceticus
sparfloxacin	MIC90 is 0.002 mg/ml	Bacteroides fragilis
sparfloxacin	MIC90 is 0.004 mg/ml	Bacteroides thetaiotaomicron
sparfloxacin	MIC90 is 0.00025 mg/ml	Citrobacter freundii
sparfloxacin	MIC90 is 0.00003 mg/ml	Citrobacter spp.
sparfloxacin	MIC90 is 0.004 mg/ml	Clostridioides difficile
sparfloxacin	MIC90 is 0.0005 mg/ml	Clostridium perfringens
sparfloxacin	MIC90 is 0.00025 mg/ml	Corynebacterium sp.
sparfloxacin	MIC90 is 0.0005 mg/ml	Enterococcus faecium
sparfloxacin	MIC90 is 0.001 mg/ml	Enterococcus sp.
sparfloxacin	MIC90 is 0.00003 mg/ml	Escherichia coli
sparfloxacin	MIC90 is 0.00003 mg/ml	Haemophilus influenzae
sparfloxacin	MIC90 is 0.00012 mg/ml	Klebsiella sp.
sparfloxacin	MIC90 is 0.00025 mg/ml	Legionella sp.
sparfloxacin	MIC90 is 0.00025 mg/ml	Listeria monocytogenes
sparfloxacin	MIC90 is 0.000015 mg/ml	Moraxella catarrhalis
sparfloxacin	MIC90 is 0.00025 mg/ml	Morganella morganii
sparfloxacin	MIC90 is 0.002 mg/ml	Mycobacterium avium
sparfloxacin	MIC90 is 0.000015 mg/ml	Neisseria gonorrhoeae
sparfloxacin	MIC90 is 0.0005 mg/ml	Peptostreptococcus sp.
sparfloxacin	MIC90 is 0.004 mg/ml	Prevotella bivia
sparfloxacin	MIC90 is 0.00025 mg/ml	Proteus mirabilis
sparfloxacin	MIC90 is 0.001 mg/ml	Providencia rettgeri
sparfloxacin	MIC90 is 0.0005 mg/ml	Providencia stuartii
sparfloxacin	MIC90 is 0.001 mg/ml	Pseudomonas aeruginosa
sparfloxacin	MIC90 is 0.00006 mg/ml	Salmonella sp.
sparfloxacin	MIC90 is 0.001 mg/ml	Serratia marcescens
sparfloxacin	-	Shigella sp.
sparfloxacin	MIC90 is 0.00006 mg/ml for strain CiproS, 0.016 mg/ml for strain CiproR, and 0.008 mg/ml for the methicillin-resistant strain	Staphylococcus aureus
sparfloxacin	MIC90 is 0.00012 mg/ml for the wild-type and 0.008 mg/ml for the methicillin-resistant strain	Staphylococcus epidermidis
sparfloxacin	MIC90 is 0.001 mg/ml	Streptococcus agalactiae
sparfloxacin	MIC90 is 0.0005 mg/ml for the wild-type strain and 0.00025 mg/ml for the strain Pen I/R	Streptococcus pneumoniae
sparfloxacin	MIC90 is 0.0005 mg/ml	Streptococcus pyogenes
sparfloxacin	MIC90 is 0.00025 mg/ml	Streptococcus viridans

Organism

Organism	UniProt	Comment	Textmining
Acinetobacter calcoaceticus	-	-	-
Bacteroides fragilis	-	-	-
Bacteroides thetaiotaomicron	-	-	-
Citrobacter freundii	-	-	-
Citrobacter spp.	-	-	-
Clostridioides difficile	-	-	-
Clostridium perfringens	-	-	-
Corynebacterium sp.	-	-	-
Enterococcus faecium	-	-	-
Enterococcus sp.	-	-	-
Escherichia coli	-	-	-
Haemophilus influenzae	-	-	-
Klebsiella sp.	-	-	-
Legionella sp.	-	-	-
Listeria monocytogenes	-	-	-
Moraxella catarrhalis	-	-	-
Morganella morganii	-	-	-
Mycobacterium avium	-	-	-
Neisseria gonorrhoeae	-	-	-
Peptostreptococcus sp.	-	-	-
Prevotella bivia	-	-	-
Proteus mirabilis	-	-	-
Providencia rettgeri	-	-	-
Providencia stuartii	-	-	-
Pseudomonas aeruginosa	-	strains AC1679-1682	-
Pseudomonas aeruginosa AC1679-1682	-	strains AC1679-1682	-
Salmonella sp.	-	-	-
Serratia marcescens	-	-	-
Shigella sp.	-	-	-
Staphylococcus aureus	-	strains CiproS and CiproR, and a methicillin-resistant strain	-
Staphylococcus aureus CiproS	-	strains CiproS and CiproR, and a methicillin-resistant strain	-
Staphylococcus epidermidis	-	wild-type and a methicillin-resistant strain	-
Streptococcus agalactiae	-	-	-
Streptococcus pneumoniae	-	wild-type strain and strain Pen I/R	-
Streptococcus pyogenes	-	-	-
Streptococcus viridans	-	-	-

Synonyms

Synonyms	Comment	Organism
DNA gyrase	-	Staphylococcus aureus
DNA gyrase	-	Haemophilus influenzae
DNA gyrase	-	Escherichia coli
DNA gyrase	-	Pseudomonas aeruginosa
DNA gyrase	-	Acinetobacter calcoaceticus
DNA gyrase	-	Serratia marcescens
DNA gyrase	-	Corynebacterium sp.
DNA gyrase	-	Neisseria gonorrhoeae
DNA gyrase	-	Mycobacterium avium
DNA gyrase	-	Streptococcus pneumoniae
DNA gyrase	-	Proteus mirabilis
DNA gyrase	-	Streptococcus pyogenes
DNA gyrase	-	Enterococcus faecium
DNA gyrase	-	Bacteroides fragilis
DNA gyrase	-	Moraxella catarrhalis
DNA gyrase	-	Staphylococcus epidermidis
DNA gyrase	-	Citrobacter freundii
DNA gyrase	-	Clostridium perfringens
DNA gyrase	-	Morganella morganii
DNA gyrase	-	Streptococcus agalactiae
DNA gyrase	-	Klebsiella sp.
DNA gyrase	-	Salmonella sp.
DNA gyrase	-	Clostridioides difficile
DNA gyrase	-	Providencia rettgeri
DNA gyrase	-	Bacteroides thetaiotaomicron
DNA gyrase	-	Providencia stuartii
DNA gyrase	-	Listeria monocytogenes
DNA gyrase	-	Shigella sp.
DNA gyrase	-	Enterococcus sp.
DNA gyrase	-	Streptococcus viridans
DNA gyrase	-	Citrobacter spp.
DNA gyrase	-	Legionella sp.
DNA gyrase	-	Prevotella bivia
DNA gyrase	-	Peptostreptococcus sp.

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Staphylococcus aureus
37	-	assay at	Haemophilus influenzae
37	-	assay at	Escherichia coli
37	-	assay at	Pseudomonas aeruginosa
37	-	assay at	Acinetobacter calcoaceticus
37	-	assay at	Serratia marcescens
37	-	assay at	Corynebacterium sp.
37	-	assay at	Neisseria gonorrhoeae
37	-	assay at	Mycobacterium avium
37	-	assay at	Streptococcus pneumoniae
37	-	assay at	Proteus mirabilis
37	-	assay at	Streptococcus pyogenes
37	-	assay at	Enterococcus faecium
37	-	assay at	Bacteroides fragilis
37	-	assay at	Moraxella catarrhalis
37	-	assay at	Staphylococcus epidermidis
37	-	assay at	Citrobacter freundii
37	-	assay at	Clostridium perfringens
37	-	assay at	Morganella morganii
37	-	assay at	Streptococcus agalactiae
37	-	assay at	Klebsiella sp.
37	-	assay at	Salmonella sp.
37	-	assay at	Clostridioides difficile
37	-	assay at	Providencia rettgeri
37	-	assay at	Bacteroides thetaiotaomicron
37	-	assay at	Providencia stuartii
37	-	assay at	Listeria monocytogenes
37	-	assay at	Shigella sp.
37	-	assay at	Enterococcus sp.
37	-	assay at	Streptococcus viridans
37	-	assay at	Citrobacter spp.
37	-	assay at	Legionella sp.
37	-	assay at	Prevotella bivia
37	-	assay at	Peptostreptococcus sp.

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	8	assay at	Staphylococcus aureus
6	8	assay at	Haemophilus influenzae
6	8	assay at	Escherichia coli
6	8	assay at	Acinetobacter calcoaceticus
6	8	assay at	Serratia marcescens
6	8	assay at	Corynebacterium sp.
6	8	assay at	Neisseria gonorrhoeae
6	8	assay at	Mycobacterium avium
6	8	assay at	Streptococcus pneumoniae
6	8	assay at	Proteus mirabilis
6	8	assay at	Streptococcus pyogenes
6	8	assay at	Enterococcus faecium
6	8	assay at	Bacteroides fragilis
6	8	assay at	Moraxella catarrhalis
6	8	assay at	Staphylococcus epidermidis
6	8	assay at	Citrobacter freundii
6	8	assay at	Clostridium perfringens
6	8	assay at	Morganella morganii
6	8	assay at	Streptococcus agalactiae
6	8	assay at	Klebsiella sp.
6	8	assay at	Salmonella sp.
6	8	assay at	Clostridioides difficile
6	8	assay at	Providencia rettgeri
6	8	assay at	Bacteroides thetaiotaomicron
6	8	assay at	Providencia stuartii
6	8	assay at	Listeria monocytogenes
6	8	assay at	Shigella sp.
6	8	assay at	Enterococcus sp.
6	8	assay at	Streptococcus viridans
6	8	assay at	Citrobacter spp.
6	8	assay at	Legionella sp.
6	8	assay at	Prevotella bivia
6	8	assay at	Peptostreptococcus sp.
6	8	assay at, dependent on strain	Pseudomonas aeruginosa